体温过低兔红细胞抗氧化能力的改变  

Changes of erythrocy tic antioxidation in hypothermic rabbits

作　　者：徐平西[1] 杨泽田 

机构地区：[1]第四军医大学分子生物学研究室

出　　处：《第四军医大学学报》1991年第2期89-91,共3页Journal of the Fourth Military Medical University

摘　　要：作者将22只家兔制成体温过低症动物模型,复温后对红细胞某些功能进行120h的连续观察,结果按时间顺序有下列变化:红细胞自溶血度显著增高;G-6-PD活性由616.7±73.2下降至514.2±48.8相对活力单位(n=11,P<0.05);红细胞自氧化敏感度从99.5±38.3上升到210.8±37.4mol MDA/mg Hb(n=7,P<0.05)。后两者间存在着线性负相关(r=-0.705;P<0.05)。以上结果说明兔经低温复温后,循环红细胞严重受损,表现为G-6-PD活性降低,抗氧化能力衰减,易发生红细胞脂质过氧化。An animal model to study deep hypothermia in rabbits was established, and some functions of rabbits' eythrocytes were observed successively after being rewarmed The various changes of the erythrocytic indices were found with time sequence as following increasing of erythrocytic osmotic fragility, inhibition of G-6-PD activity from 616.7 ± 73.2 down to 514.2 ± 48.8 relative activity unit (P<0.05); a rising erythrocyte autoxidation susceptibility from 99.5 ± 38.3 up to 210.8 ± 37.4 mol MDA/mg Hb(P<0.05). These findings show that erythrocytes of rabbits suffered from hypothermia are injuried severely and decreases in both G-6-PD activity and capacity of antioxidation result in tending to lipid peroxidation of the erythrocytic membrane.

关 键 词：低体温 红细胞 脂质过氧化 

分 类 号：R363.123[医药卫生—病理学]