代谢综合征与阿尔茨海默病的相关性研究  

The correlation between Metabolicyndrome and Alzheimer's disease research

作　　者：黄若燕[1] 任建娟[1] 韩海英[1] 唐牟尼[1] 

机构地区：[1]广东省广州市精神病医院,510370

出　　处：《精神医学杂志》2013年第3期175-177,共3页Journal of Psychiatry

基　　金：广东省广州市卫生局医药卫生科技项目(编号:20121A011098)

摘　　要：目的探讨代谢综合征(MS)各组分、心血管危险因素指标与阿尔茨海默病(AD)之间的关系。方法将58例AD患者按照中华医学会糖尿病分会制定的糖尿病诊断标准分为有代谢综合征组(MS组)和无代谢综合征组(NMS组),并测定空腹血糖、空腹胰岛素、甘油三酯、血管紧张素转化酶、超敏C反应蛋白等指标,计算胰岛素抵抗。结果 (1)MS组与NMS组比较,胰岛素和腹围均明显升高,有统计学差异(P<0.05)。(2)MS组与NMS组比较,同型半胱氨酸、胰岛素抵抗明显升高,有统计学差异(P<0.05)。(3)血管紧张素转化酶与腰围的相关性有统计学意义(P=0.021)。胰岛素抵抗与空腹血糖、空腹胰岛素相关性有统计学意义(P=0.000)。超敏C反应蛋白与甘油三酯的相关性有统计学意义(P=0.018)。血管紧张素转化酶与空腹胰岛素的相关性有统计学意义(P=0.039)。结论有MS的AD患者比无MS的AD患者有更多心血管方面的危险因素。Objective To examine the association among risk factors of cardiovascular and Alzheimerg disease （AD）. the various components of the metabolic syndrome . MS）, Method 58 patients with AD were divided into MS group and non-MS group （NMS grooup） according to the diagnostic criteria of MS by Chinese Medical Association Diabetes Branch. Blood fasting sugar, fasting insulin, triglyceride, angiotensin converting enzyme and hypersensitive C-reactive protein （hs-CRP） were evaluated in all the cases and then the insulin sensitive index （ISI） was calculated. Results （ 1 ） The level of fasting insulin and abdominal circumference in MS group were significantly higher than those in NMS group （P 〈 0.05 ）. （2） The level of homocysteine and insulin resistance in MS group were significantly higher than those in NMS group （ P 〈 0.05）. （3） The level of angiotensin converting enzyme was significantly positively correlated with abdominal circumference （P = 0. 021 ）. Level of insulin resistance was significantly positively correlated with fasting sugar （P = 0.000）, as well as fasting insulin （ P = 0. 000 ）. Level of hs - CRP was significantly negatively correlated with triglyceride （P = 0. 018 ） and level of angiotensin converting enzyme was significantly correlated with fasting insulin （ P = 0. 039）. Conclusion Vascular factors may be one of the risk factors of AD in AD patients combined with MS.

关 键 词：阿尔茨海默病 代谢综合征 危险因素 

分 类 号：R749.25[医药卫生—神经病学与精神病学]