c-myc原癌基因的表达与人甲状腺癌预后的关系  

c-myc proto- oncogene expression and prognosis in human thyroid carcinomas

作　　者：杨叶[1] 胡绍文[1] 王成济[2] 

机构地区：[1]西京医院内分泌科 [2]第四军医大学生物化学教研室

出　　处：《第四军医大学学报》1991年第4期275-277,共3页Journal of the Fourth Military Medical University

摘　　要：作者应用核酸打点杂交方法,观察原发性甲状腺癌15例、甲状腺瘤3例和正常甲状腺5例组织中c-myc原癌基因的表达.结果表明:9例甲状腺癌c-myc基因表达较正紧组织增高3-11倍.具有c-myc基因过度表达的甲状腺癌患者甲状腺癌预后指数≥66的发生率高于其他患者(P<0.05),提示c-myc基因的过度表达可能与甲状腺癌的不良预后有关.The auther reported expression of ifte r-myc gate was studled by RNA dot - blot hybridization in tumor specimens from 15 patients with promary thyraid caremomas , 3 patients with thyroid adenomas , tissues from 5 normal thyroid tissues P dATP labeled prohe of c - myc fragment of cloned gene was used to hybridize with the cellular total RNA We found that in 9 of the 15 cancer patients , c- myc proto- oncogene was over -expressed (3-11 times higher chan that in normal thyroid tissues ). Patients whose tumors showed c- myc overexpression had a greater madenec for the thyroid carcinoma prognosis indexes more than or equal to 66 than other patients (P<0.05). It suggests that overexpression of c -myc proto - oncogene may be associated with unfavourable prognosis of thyroid carcinoma .

关 键 词：癌基因 表达 甲状腺肿瘤 预后 

分 类 号：R730.231[医药卫生—肿瘤]