帕金森病轻度认知功能障碍患者的事件相关电位研究  

Event-related potentials in Parkinson's disease patients with mild cognitive impairment

作　　者：张玉虎[1] 甘蓉[1] 聂坤[1] 黄莘莘[1] 戴颖仪[1] 黄静[1] 王丽娟[1] 

机构地区：[1]广东省人民医院(广东省医学科学院)神经内科广东省神经科学研究所,广州510515

出　　处：《中华老年心脑血管病杂志》2013年第7期675-677,共3页Chinese Journal of Geriatric Heart,Brain and Vessel Diseases

基　　金：国家自然科学基金(30801219;30870863);广东省自然科学基金(10151008004000030);广东省科技计划项目(2011B080701087);广东省医学科研基金(A2010033)

摘　　要：目的探讨事件相关电位在评估帕金森病轻度认知功能障碍(PD-MCI)中的价值。方法选择PD患者110例,根据神经心理学测验评估结果分为PD-MCI组45例和认知正常组(PD-CN组)65例。另选择同期健康体检者66例(对照组)。比较各组事件相关电位成分的变化,并分析P3和N2潜伏期及波幅与神经心理学测验成绩的相关性。结果与PD-CN组比较,PD-MCI组P3和N2潜伏期明显延长,差异有统计学意义(P<0.05);与对照组比较,PD-CN组P3潜伏期延长(P<0.05)。3组间P3和N2潜伏期比较,差异有统计学意义(P=0.001,P=0.000,P=0.004,P=0.000);3组间P3波幅比较,差异无统计学意义。P3潜伏期与视觉再认、图片排列及MMSE评分呈负相关(P<0.05),N2潜伏期与视觉再认、图片排列评分呈负相关,差异有统计学意义(P<0.05)。结论事件相关电位能较客观反映认知功能,其中N2潜伏期可作为PD-MCI客观评估的指标。Objective To study the value of event-related potentials （ERP） in diagnosis of mild cog- nitive impairment （MCI） in Parkinson＇s disease （PD） patients. Methods One hundred and ten PD patients were divided into PD with MCI group （n=45） and PD without MCI group （n=65） ac- cording to their neuropsychological assessment. Sixty-six subjects who underwent health check served as a control group. Changes of ERP were compared among the 3 groups. Correlation of the latent period and amplitude of P3 and N2 with the findings in neuropsychological test was ana- lyzed. Results The latent periods of P3 and N2 were significantly longer in PD with MCI group than in PD without MCI group （P〈0.05）. The latent periods of P3 were significantly longer in PD with MCI group than in control group （P〈0.05）. The latent periods of P3 and N2 were sig- nificantly longer in PD with MCI group than in PD without MCI group and control group （P〈0.01）. No significant difference was found in the amplitude of P3 among the 3 groups. The latent period of P3 was negatively correlated with verbal paired associates, picture arrangement and MMSE score, while the N2. was correlated with verbal paired associates, picture arrangement. Con- clusion ERP can reflect the cognitive function of PD patients with MCI. The latent period of N2 can be used as an index in assessment of PD with MCI.

关 键 词：帕金森病 认知障碍 诱发电位 神经心理学测验 

分 类 号：R749.1[医药卫生—神经病学与精神病学]