军队高龄老年人阿尔茨海默病危险因素的对照研究  

A case control study on risk factors for Alzheimer's disease in advance-aged veterans of Chinese PLA

作　　者：崔博[1,2] 谭纪萍 刘丽欣[1] 兰晓阳[1] 王姮[1] 王鲁宁[1] 

机构地区：[1]解放军总医院南楼神经内科,北京100853 [2]天津市胸科医院

出　　处：《中华老年心脑血管病杂志》2013年第7期722-725,共4页Chinese Journal of Geriatric Heart,Brain and Vessel Diseases

基　　金：解放军总后勤部卫生部保健专项科研课题(07BJZ04)

摘　　要：目的探讨军队高龄患者阿尔茨海默病(Alzheimer disease,AD)可能的危险因素,分析早年电磁场暴露史与AD发生的关系。方法以流行病学调查发现的男性高龄AD患者80例为病例组,以年龄分层抽样按12的比例,从同次调查中认知功能正常的高龄老年人中随机抽取同性别150例为对照组(年龄>90岁且无足够正常对照,则按11配对)。2组危险因素调查通过查阅干休所既往病历及与知情人面访进行。采用非条件logistic回归分析AD危险因素。结果单因素分析显示,2组脑梗死、脑外伤史、痴呆家族史和电磁场暴露史比较,差异有统计学意义(P<0.05);经校正后多因素分析显示,电磁场暴露史和脑外伤史为AD发生的危险因素,OR值及95%CI分别为4.30(1.33～13.98,P<0.05)和3.41(1.15～10.14,P<0.05)。结论脑外伤史和电磁场暴露史是高龄老年人患AD的独立危险因素。Objective To study the risk factors for Alzheimer＇s disease （AD） in advance-aged vet erins of Chinese PLA by analyzing the relation between early electromagnetic field exposure and AD. Methods Eighty advance-aged AD patients served as case group and 150 advance-aged sub jects served as a control group in this study. Risk factors for AD were investigated by consulting their past medical records and interviewing with persons knowing their condition and analyzed by unconditional logistic regression analysis. Results Univariate analysis showed that ischemic stroke, history of brain trauma and family history of dementia were the more important risk fac- tors for AD than the electromagnetic field exposure （P〈0.05）. Multivariate analysis showed that history of electromagnetic field exposure and brain trauma were two risk factors for AD （OR = 4.30,95%CI：1.33-13.98,P〈0.05;OR=3.41,95%CI：1.15-10.14,P〈0.05）. Conclusion History of brain trauma and electromagnetic field exposure are two independent risk factors for AD.

关 键 词：阿尔茨海默病 脑梗死 电磁场 职业暴露 脑白质疏松症 危险因素 

分 类 号：R749.16[医药卫生—神经病学与精神病学]