脂蛋白脂酶Ser447Term多态性和卒中相关危险因素相互作用对缺血性脑卒中发病的影响  

Investigation of the interaction between the Ser447Term polymorphism of lipoprotein lipase and the stroke-related risk factors in ischemic stroke

作　　者：杨玉梅[1] 朱丹[2] 吴江[2] 

机构地区：[1]同济大学附属东方医院,上海200120 [2]吉林大学白求恩第一医院神经内科,吉林长春130021

出　　处：《中风与神经疾病杂志》2013年第6期489-492,共4页Journal of Apoplexy and Nervous Diseases

基　　金：吉林省科技厅资助项目(No.20060413-1);长春市科技局资助项目(No.2006070)

摘　　要：目的本研究旨在探讨脂蛋白脂酶(LPL)Ser447Term多态性与一些常见的卒中危险因素之间的相互影响。方法检测704个汉族缺血性脑卒中患者的基因型,根据这些患者所具有的卒中相关危险因素将其分为2型糖尿病组、高血压组、吸烟组和高脂血症组。应用聚合酶链反应-限制性片段长度多态性方法对Ser447Term的多态性进行基因分型。结果卡方(χ2)检验结果显示:在有糖尿病史的卒中患者中Ser447Term G等位基因的携带率显著高于无糖尿病史的卒中患者(χ2=7.25,P=0.007,OR=1.78,95%CI1.18～2.68)。这样的相关性并未在具有其他3个卒中相关的危险因素的患者中观察到。结论 LPL基因多态性与糖尿病的联合作用可能促成缺血性卒中的一个亚组的发病。Objective To investigate the interaction between the Ser447Term polymorphism in the lipoprotein lipase（LPL） gene and some common risk factors for stroke.Methods A total of 704 unrelated patients with ischemic stroke were recruited for genetic analysis;they were all of Han Chinese origin.These patients were classified into subgroups based on their exposure to stroke-related risk factors,including type 2 diabetes,hypertension,smoking,and hyperlipidemia.The Ser447Term polymorphism was genotyped by PCR-based restriction fragment length polymorphism analysis.Results The chi-square（χ2） test showed that the frequency of Ser447Term G allele was significantly higher in stroke patients with a history of diabetes than in those without a history of diabetes（χ2=7.25,P=0.007,OR=1.78,95%CI 1.18~2.68）.Allelic association was not observed in patients exposed to the other three stroke-related risk factors.Conclusion The combined effect of the LPL gene polymorphisms and diabetes may contribute to the development of a subgroup of ischemic stroke.

关 键 词：缺血性卒中 糖尿病 脂蛋白脂酶 Ser447Term多态性 单核苷酸多态性(SNP) 

分 类 号：R743.32[医药卫生—神经病学与精神病学]