C型凝集素受体Langerin的研究进展  

Langerin, a C-type lectin receptor

作　　者：王苏[1] 姚煦[1] 

机构地区：[1]中国医学科学院北京协和医学院皮肤病研究所,南京210042

出　　处：《国际皮肤性病学杂志》2013年第4期260-263,共4页International Journal of Dermatology and Venereology

基　　金：国家自然科学基金（81171501）;江苏省自然科学基金（BK2011127）

摘　　要：朗格汉斯细胞是存在于上皮能提呈抗原的树突细胞。Birbeck颗粒是其电子显微镜下的特征性细胞器，Langerin（CD207）是其细胞表型特征。Langerin除了表达于朗格汉斯细胞表面，也表达在真皮的树突细胞和机体其他组织细胞。近年来研究发现，Langerin能降低HIV-1感染的风险、抗真菌感染、调节接触超敏反应、辅助朗格汉斯细胞相关疾病的诊断及增强疫苗功效，希望能为探索相关皮肤疾病新的预防和治疗手段提供思路。Langerhans cells are antigen-presenting dendritic cells （DCs） that reside in epithelia. Under an electron microscope, Birbeck granules are a characteristic organelle of Langerhans cells, and the C- type lectin receptor langerin （CD207） is their phenotypic hallmark. In addition to Langerhans cells, dermal DCs and other tissue ceils also express Langerin. Recent studies have revealed that Langerin can reduce the risk of human immunodeficiency virus （HIV） infection, fight against fungal infection, regulate contact hypersensitivity, and improve vaccine efficacy. Also, Langerin has been applied in the diagnosis of Langerhans cell-related diseases. The authors briefly review progress in research on Langerin structure, function and clinical application, in hope to provide new clues to the prevention and treatment of related skin diseases.

关 键 词：朗格尔汉斯细胞 外源凝集素类 C型 LANGERIN CD207 

分 类 号：R3[医药卫生—基础医学]