uPA和VEGF与儿童造釉细胞型颅咽管瘤复发的相关性研究  

Research on the correlation between the uPA and VEGF recurrence of admantionmatous craniopharyngioma

作　　者：邢树山[1] 刘文庆[2] 胡万宁[3] 赵喜庆[3] 宫剑[1] 

机构地区：[1]首都医科大学附属北京天坛医院神经外科,100050 [2]宁夏医科大学总医院神经外科 [3]河北联合大学附属唐山市人民医院肿瘤科

出　　处：《中华神经外科杂志》2013年第6期561-564,共4页Chinese Journal of Neurosurgery

基　　金：国家自然科学基金，北京市教委科技计划重点项目

摘　　要：目的探讨尿激酶型纤溶酶原激活物（uPA）和血管内皮生长因子（VEGF）表达与造釉细胞型颅咽管瘤复发的关系。方法应用免疫组化检测48例造釉细胞型颅咽管瘤标本（原发组28例，复发组20例）中uPA和VEGF的表达。结果造釉细胞型颅咽管瘤中，uPA在复发组的总阳性表达率95．0％，明显高于原发组的42．9％（Z=-3．396，P〈0．05）；VEGF在复发组的总阳性表达率90．0％，明显高于原发组的64．3％（Z=-2．909，P〈0．05）。复发组造釉细胞型颅咽管瘤中uPA与VEGF表达呈正相关（r=0．534，P〈0．05），原发组造釉细胞型颅咽管瘤中uPA与VEGF表达无明显相关性（r=-0．105，P〉0．05）。结论高水平的uPA和VEGF能协同促进细胞外基质的降解和血管生成的，促进肿瘤的复发转移，可以作为儿童造釉细胞型颅咽管瘤重要的生物学行为预测和预后指标。Objective To explore the expression of urokinasetype plasminogen activator （uPA） and vascular endothelial growth factor （VEGF） in adamantinomatous craniopharyngioma and analyze the correlation between the level of these markers and adamantimous craniopharyngiomas recurrence. Methods The level of uPA and VEGF was tested by immunohistochemistry （IHC） in 48 cases of ACP, including 28 cases of primary group and 20 cases of recurred group. Results The expression level of uPA in recurred group was significantly higher than primary group （95.0% vs. 42. 9% , Z = - 3. 396, P 〈 0. 05）. The expression level of VEGF in recurred group was significantly higher than primary group （90. 0% vs. 64. 3%, Z = -2. 909, P 〈0. 05）. There were mutually positive correlations between uPA and VEGF expressions in recurrent group of adamantimous craniopharyngiomas （r = 0. 534, P 〈 0. 05 ）. Conelutions uPA and VEGF may be the potential biomarkers to evaluate the inclination of invasion and recurrence in adamantimous craniopharyngiomas.

关 键 词：尿激酶型纤溶酶原激活物 血管内皮生长因子 造釉细胞型颅咽管瘤 复发 相关性 

分 类 号：R73[医药卫生—肿瘤]