APE/Ref-1在消化系统肿瘤中的研究进展  

Advances in Study on APE/Ref-1 in Digestive System Tumors

作　　者：宋军民[1] 李琳[1] 李岩[1] 

机构地区：[1]中国医科大学附属盛京医院消化内科,110004

出　　处：《胃肠病学》2013年第6期374-377,共4页Chinese Journal of Gastroenterology

摘　　要：DNA碱基切除修复(BER)参与由各种原因导致的DNA损伤修复过程,是维持基因组DNA完整性的一个重要修复机制。脱嘌呤/脱嘧啶核酸内切酶/氧化还原因子-1(APE/Ref-1)是BER过程的关键酶之一,具有DNA修复、氧化还原激活、基因表达调控等多种生物学功能,近年研究显示APE/Ref-1与胃癌、结直肠癌、胰腺癌的发生关系密切。本文就APE/Ref-1在消化系统肿瘤中的研究进展作一综述。DNA base excision repair（BER） is involved in the repair process of DNA damage due to all kinds of causes.It plays an important role in maintaining the integrity of genomic DNA.Apurinic / apyrimidinic endonuclease / redox factor-1（APE / Ref-1） is a key enzyme for BER.It has various biological functions such as DNA repair,oxidoreduction activation and regulation of gene expression.Recent studies demonstrated that APE / Ref-1 had a close association with gastric cancer,colorectal cancer and pancreatic cancer.This article reviewed the advances in study on APE / Ref-1 in digestive system tumor.

关 键 词：DNA-(无嘌呤或无嘧啶位点)裂合酶 氧化还原因子-1 消化系统肿瘤 DNA修复 

分 类 号：R735[医药卫生—肿瘤]