云南省15个特有少数民族7岁以下儿童地中海贫血的调查研究  

Epidemiological Study on Thalassaemia Among the Children Under 7Years Old From Yunnan Province With Unique Ethnic Minority Origin

作　　者：姚莉琴[1] 邹团标[1] 刘锦桃[1] 全星[1] 陈谦[1] 杨发斌[1] 忽丽莎[1] 王兴田[1] 赵钟鸣[1] 

机构地区：[1]云南省妇幼保健院,昆明650051

出　　处：《中华妇幼临床医学杂志（电子版）》2013年第3期291-297,共7页Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition)

摘　　要：目的了解云南省10个州(市)的22县市的15个特有少数民族及汉族儿童地中海贫血(Thalassaemia)的流行病学现状。方法 2009年6月至2011年9月,对云南省14 088名7岁以下特有少数民族及汉族儿童的地中海贫血情况进行筛查,包括血液分析、血红蛋白(Hb)电泳及基因分析等实验室检查,并进行统计学分析(本研究遵循的程序符合本院人体试验委员会制定的伦理学标准,得到该委员会批准,并征得调查对象监护人的知情同意)。结果 15个特有少数民族儿童的地中海贫血发生率为20.9%(1793/8559),其中β-地中海贫血发生率11.3%(964/8559),α-地中海贫血发生率9.7%(829/8559)。靠云南边境地区地中海贫血检出率相对高,尤以德宏州居首(43.1%),其后依次为西双版纳州(33.7%),怒江州(26.3%),临沧市(10.7%),保山市(9.8%)。边境地区民族的地中海贫血发生率高于非边境地区;β-地中海贫血检出率阿昌族居首位(40.6%);α-地中海贫血以傣族(西双版纳州)居首位(22.2%)。α-,β-地中海贫血发生率各地均有差异。结论儿童地中海贫血发生率在云南省15种特有少数民族存在差异,且地区差异大于民族差异。云南西南部及当地民族是地中海贫血高发地区和高发民族。Objective To investigate the epidemiological status of Thalassaemia among the children under 7years old from Yunnan province with 15unique ethnic minority.Methods From June 2009to September 2011,blood samples from 14 088 children were tested by blood cell automatic analysis,hemoglobin electrophoresis,and genetic analysis.The study protocol was approved by the Ethical Review Board of Investigation in Human Being of Yunnan Provincial Maternal and Child Health Hospital.Informed consent was obtained from all participates＇parents.Results The incidence rates of Thalassaemia,β-Thalassemia andα-Thalassemia were 20.9%（1793/8559）,11.3%（964/8559）,and 9.7%（829/8559）,respectively.Significant difference were also detected among children from different ethnic groups as well as regions.The detection rate of Thalassaemia of border areas was higher than that of non-border areas.The highest detection rate of all the regions was 43.1%in Dehong city,followed by 33.7%in Xishuangbanna,26.3%in Nujiang,10.7%in Lincang,9.8%in Baoshang.Conclusions Occurrence of Thalassemia varies substantially between different ethnic groups as well as regions,especially Southwestern areas.This study may provide a valuable basis for counseling of Thalassemia in Yunnan province.

关 键 词：儿童 地中海贫血 特有少数民族 流行病学 云南 

分 类 号：R725.5[医药卫生—儿科]