番茄红素对2型糖尿病患者炎症因子与颈动脉内膜中层厚度的影响  

EFFECTS OF LYCOPENE ON CYTOKINES AND CAROTID INTIMA-MEDIA THICKNESS IN TYPE 2 DIABETIC PATIENTS

作　　者：曾瑶池 赵恒侠[2] 李金花[2] 刘燕平[2] 王太芬[2] 穆桂萍[3] 

机构地区：[1]深圳市中医院营养科,深圳518033 [2]深圳市中医院营养科内分泌科,深圳518033 [3]深圳市中医院中心实验室,深圳518033

出　　处：《营养学报》2013年第3期268-272,共5页Acta Nutrimenta Sinica

基　　金：广东省深圳市科技计划项目(No.201103377);广东省医学科研基金立项课题(No.A2012568)

摘　　要：目的探讨2型糖尿病(T2DM)患者血清炎症因子水平与颈动脉内膜中层厚度(CIMT)的关系及番茄红素(Lyc)的干预效果。方法选取T2DM患者130例随机分为:A组(干预组)64例,给予Lyc胶囊30mg/d;B组(对照组)66例,不服用Lyc但给予安慰剂。两组患者均采集入组时和干预后6个月的空腹血清,监测血糖、生化指标、炎症因子和CIMT。结果 Lyc干预6个月后,A组IL-6、TNF-α、hs-CRP、NF-κB水平显著降低,均低于B组(P<0.05),B组上述炎症因子水平变化差异无统计学意义(P>0.05);干预后A组患者CIMT及颈动脉斑块发生率较干预前及B组明显下降;T2DM患者CIMT与炎症因子水平相关,多元回归分析表明NF-κB、HbAlc和hs-CRP是CIMT的独立影响因素(决定系数R2=0.612,P=0.000)。结论 T2DM患者炎症因子水平是CIMT的独立预测因素,Lyc可能通过降低炎症因子水平而抑制T2DM患者早期动脉粥样硬化的发生、发展。Objective To examine whether inflammatory cytokines were related to carotid artery intima media thickness （CIMT） in type 2 diabetic patients and evaluate the effect of lycopene （Lyc） on them. Methods One hundred and thirty T2DM patients without major vascular complications were recruited and randomly divided into two groups： Lyc treated group （A group, n=64） and control group （B group, n-66）. In A group, the patients were given orally Lyc 30 mg twice daily for 6 months. In B group, the patients were given the placebo for 6 mo. Their biochemical indicators and inflammatory cytokines and carotid intima-media thickness were measured before and after the treatment. Results After treatment with Lyc, the interleukin-6 （IL-6）, tumor necrosis factor （TNF-a ）, （hypersensitive 3 C-reactive, hs-CRP）, and nuclear factor kappa B （NF-KB） decreased significantly （P〈0.05）. Most data had no marked changes in the B group （P〉0.05）. After treatment with Lyc, CIMT and the incidence of carotid atherosclerotic （AS） plaque decreased significantly （P〈0.05）. Pearson correlation analysis showed that CIMT was positively correlated with IL-6, TNF-ct, hs-CRP and NF-B （P〈0.05）. Multivariate regression analysis showed that NF-B, HbAlc and hs-CRP concentration were independent predictors of CIMT in this cohort （R2 =0.612, P=0.000）. Conclusion High concentration of inflammatory cytokines is risk factor for preclinical AS in T2DM patients. Lyc may delay the occurrence and development of AS via decreased inflammatory cytokines concentration.

关 键 词：2型糖尿病 炎症因子 颈动脉内膜中层厚度 番茄红素 

分 类 号：R587.1[医药卫生—内分泌]