急性单核细胞白血病患者外周血和骨髓TCR Vβ亚家族T细胞的倾斜性分布特点  

The Feature of Skewing Distribution of TCR Vβ T Cells from Peripheral Blood and Bone Marrow in Patients with AML-M_5

作　　者：杨力建[1] 李扬秋[1] 陈少华[1] 祁明芳[1] 卢育洪[2] 罗更新[2] 

机构地区：[1]暨南大学医学院血液病研究室,广州510632 [2]暨南大学医学院第一附属医院血液科,广州510632

出　　处：《中国实验血液学杂志》2000年第3期196-198,共3页Journal of Experimental Hematology

基　　金：国家自然科学基金 ( 3 9870 3 5 8) ;广东省自然科学基金( 980 70 5 );广州市科委重点科技攻关计划 ( 98 z 0 3 9 0 1);广东省医学科研基金 (A19992 71)资助项目

摘　　要：采用RT PCR扩增急性单核细胞白血病 (AML M5)患者外周血和骨髓单个核细胞的TCRVβ 2 4个亚家族基因 ,分析其TCRVβ亚家族的利用情况。结果发现 ,不同标本中可检测到 1- 19Vβ亚家族的T细胞 ,不同患者外周血和骨髓中TCRVβ亚家族T细胞分布不尽相同。研究结果提供了AMLThe TCR Vβ 24 subfamily genes were amplified in peripheral blood and bone marrow mononuclear cells from 5 cases with acute monocytic leukemia (AML-M 5) using RT-PCR, to observe the distribution of TCR Vβ subfamilies. The results indicated that 1-19 Vβ subfamily T cells could be identified in different samples from AML-M 5 cases. The variation of distribution of TCR Vβ subfamily T cells could be found in different individual samples. The results provided the feature of cell immune function change in skewed distribution of TCR Vβ subfamily T cells from peripheral blood and bone marrow of patients with AML-M 5.

关 键 词：白血病 T细胞 受体 VΒ基因 聚合酶链反应 

分 类 号：R733.710.3[医药卫生—肿瘤]