Curative effect of Dingqi analgesic patch on cancer pain:a single-blind randomized controlled trail  

作　　者：Changjun Wang Wei Tan Xuhui Huang Tingting Fu Juze Lin Junmin Bu Guojian Wei Yu Du 

机构地区：[1]Department of Traditional Chinese Medicine,Guangdong General Hospital,Guangdong Academy of Medical Sciences [2]Guangdong Geriatric Institute

出　　处：《Journal of Traditional Chinese Medicine》2013年第2期176-180,共5页中医杂志（英文版）

基　　金：Supported by the Administration of Traditional Chinese Medicine of Guangdong Province,China (No. 2010431)

摘　　要：OBJECTIVE:To observe the curative effect of an acupoint application with a Dingqi analgesic patch on moderate to severe pain caused by liver cancer.METHODS:Forty patients with moderate to severe pain caused by liver cancer were randomly divided intoatreatmentgroup(TG)andacontrolgroup(CG).Patients with moderate pain were given 100 mg qd of a sustainably released tablet of tramadol hydrochloride;patientswithseverepainweregiven4.2mg q3d of the fentanyl transdermal system.The ashi points Ganshu(BL 18),Danshu(BL 19) and Qimen(LR 14) were chosen for the acupoint application intervention.CG patients were given a sham patch and TG patients were given a Dingqi analgesic patch.A visual analogue scale(VAS) was used before treatment and after 1,3,6,9 and 12 days of treatment.The Karnofsky score was measured before treatment and after 12 days of treatment.Any main adverse reactions(e.g.nausea,constipation,dizziness and headache) were recorded after 6 and 12 days of treatment.Any skin side effects(i.e.skin irritation and allergic reactions) were recorded.RESULTS:The VAS in TG was significantly lower than that in CG after 3,6,9 and 12 days of treatment(P<0.05).There was no significant difference in the Karnofsky score before treatment and after 12 days of treatment between CG and TG.There were also no significant differences in the main adverse reactions or skin side effects after 6 and 12 days of treatment between CG andTG(P>0.05).CONCLUSION:The Dingqi analgesic patch can enhance the analgesic effect of tramadol and fentanyl.OBJECTIVE： To observe the curative effect of an acupoint application with a Dingqi analgesic patch on moderate to severe pain caused by liver cancer. METHODS： Forty patients with moderate to severe pain caused by liver cancer were randomly divided into a treatment group （TG） and a control group （CG）. Patients with moderate pain were given 100 mg qd of a sustainably released tablet of tramadol hydro- chloride; patients with severe pain were given 4.2 mg q3d of the fentanyl transdermal system. The ashi points Ganshu （BL 18）, Danshu （BL 19） and Qimen （LR 14） were chosen for the acupoint application in- tervention. CG patients were given a sham patch and TG patients were given a Dingqi analgesic patch. A visual analogue scale （VAS） was used be- fore treatment and after 1, 3, 6, 9 and 12 days of treatment. The Karnofsky score was measured be- fore treatment and after 12 days of treatment. Any main adverse reactions （e.g. nausea, constipation, dizziness and headache） were recorded after 6 and12 days of treatment. Any skin side effects （i.e. skin irritation and allergic reactions） were recorded. RESULTS： The VAS in TG was significantly lower than that in CG after 3, 6, 9 and 12 days of treat- ment （P〈0.05）. There was no significant difference in the Karnofsky score before treatment and after 12 days of treatment between CG and TG. There were also no significant differences in the main ad- verse reactions or skin side effects after 6 and 12 days of treatment between CG and TG （P〉0.05）. CONCLUSION： The Dingqi analgesic patch can en- hance the analgesic effect of tramadol and fen- tanyl.

关 键 词：ANALGESICS Liver neoplasms Pain Acu-puncture points Randomized controlled trail 

分 类 号：R273[医药卫生—中西医结合]