光动力疗法治疗脉络膜新生血管性疾病的短期疗效观察  

The short-term efficacy observation by photodynamic therapy for choroidal neovascularization

作　　者：哈少平[1] 王利明[1] 

机构地区：[1]宁夏回族自治区人民医院眼科医院,宁夏银川750001

出　　处：《宁夏医学杂志》2013年第6期507-509,共3页Ningxia Medical Journal

摘　　要：目的应用维替泊芬光动力疗法(PDT)治疗湿性年龄相关性黄斑变性(wAMD)、病理性近视(PM)和特发性脉络膜新生血管(ICNV)疾病的临床效果。方法临床确诊71例(82眼)的CNV患者行维替泊芬PDT治疗,患者观察治疗前后的视力、CNV病灶大小及渗漏情况,以及黄斑中心凹视网膜厚度(CMT)等。结果湿性年龄相关性黄斑变性39例(46眼),病理性近视11例(13眼),特发性脉络膜新生血管21例(23眼)。各组治疗6个月后最佳矫正视力稳定和提高的患者各组分别为89.1%,92.3%和91.3%;CNV渗漏停止或减少者各组分别为58.7%,61.5%和73.9%;黄斑中心凹视网膜厚度较治疗前减轻者在6个月各组分别为90.5%,79.4%和88.1%;平均次数分别为1.15,1.09和1.04。结论维替泊芬光动力疗法可有效地改善或稳定湿性年龄相关性黄斑变性、病理性近视和特发性CNV患者的视力,控制病变进展,6个月随访结果安全有效。Objective To evaluate the short -term efficacy of photodynamic therapy （PDT） for choroidal neovascularization （CNV） in wet age -related macular degeneration （wAMD）, pathological myopia （PM） and idiopathic choroidal neovascularization （IC- NV）. Methods 71 cases （82 eyes） diagnosed as CNV were treated with PDT and the followed - up 6 months. The best corrected visualacuity, fundus fluorescein angiography （FFA） ,indocyanine green angiography （ICGA） and optic coherence tomography （OCT）, the size and leakage of CNV lesion, as well as central macular thickness before and after PDT were compared for evaluating the therapeutic effects of PDT. Results 39 cases （46 eyes） with wAMD,11 cases （13 eyes） with PM and 21 cases （23 eyes） with idiopathic CNV were in- cluded in the study. The mean times of PDT treatment for wAMD, PM and idiopathic CNV were 1.15,1.09 and 1.04,respectively. After PDT,the rates of best correct visualacuity （BCVA） which improved or kept stable were 89.1%, 92.3 % and 91.3% respectively, the rates of decrease or disappearance of fluorescein leakage ,58.7% ,61.5% and 73.9%, respectively. And the rates of reduction of intra - and subretinal fluid were 79.4% ,90.5% and 88. 1% respectively in patients wAMD,PM and idiopathic CNV. Conclusion PDT could improve or stabilize the visual function of AMD, PM and idiopathetic CNV patients, as well as making the progression of disease under control. It is safe and effective for CNV patients in the short follow - up period.

关 键 词：光动力疗法 脉络膜新生血管 年龄相关性黄斑变性 

分 类 号：R773.4[医药卫生—眼科]