天津地区女性人乳头瘤病毒感染情况及亚型分布特征分析  

Infection and genotype distribution of human papilloma virus in females in Tianjin

作　　者：吴林玲[1] 闫颖[1] 韩志平[1] 

机构地区：[1]天津中医药大学第一附属医院妇科,天津300193

出　　处：《海南医学》2013年第13期1922-1925,共4页Hainan Medical Journal

摘　　要：目的研究23种HPV基因亚型在天津地区女性中的感染状况以及亚型分布特征,为预防HPV感染和宫颈癌防治提供依据。方法利用DNA杂交技术检测妇科门诊样本,并进行基因分型,比较不同亚型流行病学的特点。结果 3350例样本中HPV感染者1048例,感染率为31.28%,其中高危亚型检出652例,占感染者的62.21%,低危亚型229例,占21.85%,同时感染高危亚型和低危亚型的167例,占15.93%。各年龄组均以单重感染为主,其次为二重感染。在5个年龄组中,≤25岁年龄段感染比例最高。23个亚型中以16型最多,其次为58型和56型。结论天津地区女性HPV感染以单重感染为主,高危亚型的感染具有一定优势;高危亚型中,HPV16、58和56为主要感染亚型。Objective To study the prevalence and molecular epidemiological characteristics of 23 geno- types of human apillomavirus （HPV） inTianjin, and to provide theoretical basis for preventing and treating uterine cer- vical cancer. Methods All samples were detected for HPV genotypes by using DNA hybridization technique, and the molecular epidemiological characteristics of 23 HPV types were compared. Results Among the 3 350 samples, 1 048 cases were HPV, with the positive rate of 31.28%; 652 cases belonged to high-risk type only, accounting for 62.21% of I-IPV positive cases; 229 （21.85%） cases belonged to low-risk type, while 167 （15.93%） cases were mixed with high-risk type and low-risk type. Subtype HPVI6 occupied the first of all high-risk types, followed by subtype HPV58 and HPV56. The most common HPV infection in 5 age groups was single genotTpe, followed by double HPV gcnotypes. Compared with other age groups, the infection rate of the group with age 425 years old was the high- est. HPVI6 genotype was the most common HPV infection type, and I-IPV58 and HPV56 are the major subtypes. Conclusion The most common HPV infection is single genotype in Tianjin. The predominate high risk subtype are HPV16, I-IPV58 and HPV56.

关 键 词：人乳头瘤病毒 基因分型 DNA杂交 

分 类 号：R730.261[医药卫生—肿瘤]