FAK、FAKpY397和Src在肝细胞癌中的表达和意义  

Expressions and significances of FAK,FAKpY397 and Src in hepatocellular carcinoma

作　　者：谷艳娇[1] 张敬坤[2] 包翠芬[2] 苏荣健[2] 

机构地区：[1]辽宁医学院附属第一医院病理科,锦州121001 [2]辽宁医学院科学实验中心,锦州121001

出　　处：《重庆医科大学学报》2013年第8期851-854,共4页Journal of Chongqing Medical University

基　　金：国家自然科学基金资助项目(编号:81172048)

摘　　要：目的:探讨黏着斑激酶(focal adhesion kinase,FAK)、磷酸化黏着斑激酶(phospho-FAK Y397,FAKpY397)和类固醇激素受体共活化因子(sceroid recptor coactivator,Src)在不同分化程度肝细胞癌(hepatocellular carcinoma,HCC)中的表达情况以及三者的相关性。方法:通过免疫组织化学法和人工计数法检测44例HCC组织及8例癌旁正常肝脏组织中FAK、FAKpY397和Src的表达。结果:FAK、FAKpY397和Src在HCC组织中表达均高于正常肝脏组织(P=0.027、P=0.041、P=0.030)且三者均与HCC分化程度有关(P=0.026、P=0.045、P=0.005),FAK和Src低分化组阳性率高于高分化组(P=0.015、P=0.002)。HCC组织中三者表达两两之间呈正相关(P=0.000、P=0.000、P=0.000)。结论:HCC组织中FAK、FAKpY397和Src表达与HCC分化程度有关;FAK和Src低分化组阳性率高于高分化组且三者相互之间存在一定相关性。Objective：To detect the expressions of focal adhesion kinase（FAK）, phospho-focal adhesion kinase Y397 （FAKpY397） and sceroid recptor c oactivator（Src） in heaptocellular carcinoma（HCC） and the relationship among them. Methods：Expressions of FAK, FAKpY397 and Src in 8 cases of normal tissues and 44 cases of HCC tissues were detected by immunohistochemical techniques and manual counting. Results：Expressions of FAK, FAKpY397 and Src were higher in HCC tissues than in normal tissues（P=O.027, P= 0.041, P=-O.030） and had relationship with the differentiation of HCC （P=-0.026, P=0.045, P=-O.O05）. Expressions of FAK and Src were higher in low differentiated HCC than in high differentiated HCC（P=-O.O15,P=-0.002）. Positive relationship was found between expres- sions of FAK, FAKpY397 and Src in HCC tissues （P=O.O00, P=O.OOO,P=O.000）. Conclusions：Expressions of FAK, FAKpY397 and Src in HCC tissues have relationship with the differentiation of HCC. Expressions of FAK and Src are higher in low differentiated HCC than in high differentiated HCC and correlation is existed between them.

关 键 词：黏着斑激酶 磷酸化黏着斑激酶 类固醇激素受体共活化因子 肝细胞癌 

分 类 号：R735.7[医药卫生—肿瘤]