动脉灌注蟾酥、丹参、苦参碱联合TACE对肝癌患者免疫功能的影响  

Influence of toad venom,salvia miltiorrhiza and matrine combined with transcatheter arterial chemoembolization on the immune function of the patients with hepatocellular carcinoma

作　　者：王前程[1] 陈炜[1] 陈大庆[1] 徐允鹏[1] 闫如虎[1] 吴媛媛[1] 

机构地区：[1]安徽中医学院第一附属医院介入中心,安徽合肥230031

出　　处：《胃肠病学和肝病学杂志》2013年第7期632-634,共3页Chinese Journal of Gastroenterology and Hepatology

基　　金：安徽中医学院临床科学研究基金项目(2009LC1-042B)

摘　　要：目的观察动脉灌注蟾酥、丹参、苦参碱联合TACE对原发性肝癌患者免疫功能的影响。方法对48例经影像学及病理学确诊的肝癌患者随机分为两组:研究组和对照组,研究组行经肝动脉灌注蟾酥、丹参、苦参碱联合TACE治疗,对照组予以单纯TACE治疗,比较两组治疗前后T细胞亚群的变化。结果同治疗前相比,动脉灌注蟾酥、丹参、苦参碱联合TACE治疗组CD3+、CD4+轻度下降(P>0.05)、CD8+轻度升高(P>0.05),单纯TACE治疗组CD3+、CD4+明显下降(P<0.01)、CD8+升高(P<0.01),研究治疗组与对照治疗组比较,治疗后的CD3+、CD4+、CD8+改变差异有统计学意义(P<0.05)。结论 TACE治疗可引起肝癌患者免疫功能的下降,联合动脉灌注蟾酥、丹参、苦参碱可有效保护TACE引起的肝癌患者免疫功能的下降。Objective To observe the effect of toad venom, salvia miltiorrhiza and matrine combined with interventional treatment on hepatocellular carcinoma, and approach the influence of the immune function in patients. Methods 48 patients with hepatocellular carcinoma were randomly divided into 2 groups： treatment group with 24 cases was treated by transcatheter arterial chemoembolization （TACE） combined with toad enom, salvia miltiorrhiza and matrine infu- sion ; control group with 24 cases was treated by TACE only. After treatment, immune function was observed. Results Compared with pre-treatment, CD^3＋ , CD^4＋ levels were decreased, and the level of CD^8＋ was increased after the operation in treatment group （ P 〈 0.05 ）. In control group, CD^3＋ , CD^4＋ levels were significantly decreased, and the level of CD^8＋ significant increased after the operation （P 〈 0.01 ） . There were significant difference between the two groups （P 〈 0.05）. Conclusion TACE can inhibit the immune function of the patients with hepatocellular carcinoma. Toad enom, salvia miltiorrhiza and matrine combined with TACE can advance immune function of HCC patients after TACE.

关 键 词：原发性肝癌 肝动脉化疗栓塞 蟾酥 丹参 苦参碱 T细胞亚群 

分 类 号：R735.7[医药卫生—肿瘤]