密蒙花方对单纯型糖尿病视网膜病变患者视网膜功能的影响  

Effect of Buddleia prescription on visual function in non-proliferative diabetic retinopathy

作　　者：接传红[1] 高健生[1] 严京[1] 郭欣璐[1] 金明[2] 徐冰[3] 宋剑涛[1] 吴正正[1] 陈子燕[1] 许超[1] 赵丹丹[1] 

机构地区：[1]中国中医科学院眼科医院,100040 [2]中日友好医院 [3]北京世纪坛医院

出　　处：《中国中医眼科杂志》2013年第3期157-160,共4页China Journal of Chinese Ophthalmology

基　　金：科技部公益基金(2005DIB1J170)

摘　　要：目的观察密蒙花方对糖尿病视网膜病变眼底表现、视野平均敏感度(MS)、视网膜电图震荡电位(ERG-Ops)变化的影响。方法将确诊为气阴两虚的非增殖期糖尿病视网膜病变患者245例,采取随机平行对照研究方法,试验组124例,对照组121例,试验组给予密蒙花方,对照组给予羟苯磺酸钙,连续用药3个月,观察治疗前后眼底病变和视野MS、ERG-Ops的变化。结果试验组眼底病变疗效37.55%;对照组8.2%,试验组疗效优于对照组(P<0.01);试验组和对照组治疗前后MS均提高(P<0.05),但2组间比较差异无统计学意义;试验组Ops中的OP2、OP3、OP4波潜伏期缩短,与对照组比较差异有统计学意义(P<0.05)。结论中药密蒙花方可改善非增殖期糖尿病视网膜病变的眼底状况,提高视野MS值,缩短ERG-Ops潜伏期。OBJECTIVE To observe the change of Buddleia prescription on fundus syndromes, the mean sensitivity of vision field （MS） and ERG oscillatory potentials （ERG-Ops） of non-proliferative diabetic retinopathy （NPDR）. METHODS Using randomized, parallel, controlled study methods, 245 cases of NPDR patients diagnosed with qi and yin deficiency were divided into therapeutic and control groups. Therapeutic group used Buddleia prescription and control group used Calcium Dobesilate.After three months of treatment,the fundus syndromes, MS and ERG-Ops were checked. RESULTS Efficacy rate of fundus syndromes of treatment group was 37.55%, and control group was 8.2%. Treatment group was superior to the control group （P〈0.05）. MS of both treatment and control groups were improved （P〈0.05）. In treatment group, the latency of 02, 03, 04 peak in Ops were shortened （P〈0.05）. CONCLUSIONS Buddleia prescription could improve retinopathy, fundus syndromes and MS. It could shorten the incubation period ERG-Ops.

关 键 词：糖尿病视网膜病变 密蒙花方 眼底病变 视野平均敏感度 视网膜电图振荡电位 

分 类 号：R774.1[医药卫生—眼科]