润目灵联合针刺治疗水样液缺乏性干眼的临床研究  

Clinical study on effect of Runmuling plus acupuncture on patients with aqueous tear deficiency (ATD)

作　　者：李凯[1] 王育良[1] 龚佳怡[1] 

机构地区：[1]江苏省中医院,南京210029

出　　处：《中国中医眼科杂志》2013年第3期165-168,共4页China Journal of Chinese Ophthalmology

基　　金："十一五"国家科技支撑计划(2007BAI20B054)

摘　　要：目的观察润目灵联合针刺综合疗法治疗水样液缺乏性干眼的临床疗效。方法 560例水样液缺乏性干眼患者来自6个眼科临床中心,采用区组随机方法,分为中药润目灵组(170例)、润目灵联合针刺综合疗法组(169例)和西药对照组(221例)3组,分别予中医综合治疗(口服中药润目灵颗粒联合针刺)以及右旋糖酐羟丙甲纤维素(泪然)滴眼液点眼,疗程均为8周,比较3组患者泪液分泌量、泪膜破裂时间、角膜染色和症状积分变化情况。结果润目灵组和中医综合疗法组的疗效在症状积分、证候显愈率以及总有效率方面均优于右旋糖酐羟丙甲纤维素滴眼液组(P<0.05),对泪液分泌量和泪膜破裂时间两个指标的改善亦明显优于西药组(P<0.01);而在证候显愈率、总有效率和症状积分改善方面,中医综合疗法又优于单纯润目灵治疗(P<0.05)。结论润目灵联合针刺综合疗法和单纯润目灵治疗对于水样液缺乏性干眼是有效的,在增加泪流量、延长泪膜破裂时间,减轻角膜病变和改善干眼症状方面都有一定的作用,并且综合疗法组疗效优于单纯润目灵。OBJECTIVE To investigate the effect of Runmuling plus Acupuncture on tears of the patients with A TD. METHODS Five hundred and sixty patients with ATD were randomly divided into integrated Runmuling group （170 cases）, Runmuling plus acupuncture therapy group （169 cases）, and tear naturals Ⅱ group （221 eases）. The patients had been treated for 8 weeks in three groups. RESULTS Schirmer-Ⅰ test, Breakup time of tear film, dry eye symptom and total effective rate of syndrome were statistically significant between two TCM therapy groups and tear naturals Ⅱ group after 8 weeks （P〈0.05） ; Dry eye symptom and total effective rate of syndrome were statistic significance between Integrated TCM therapy group and Runmuling group after 8 weeks （P〈0.05）. CONCLUSIONS Integrated TCM therapy was obviously effective on treatment of AMD.

关 键 词：干眼症 中医综合治疗 润目灵 针炙 疗效 

分 类 号：R777.34[医药卫生—眼科]