支架置入联合3D-CRT治疗中晚期食管癌疗效分析  

Efficacy of esophageal stent inserting combined with three-dimensional conformal radiotherapy on advanced esophageal carcinoma

作　　者：陈大朝[1] 纪荣佳[1] 庄建发[1] 管凯[1] 

机构地区：[1]解放军第一七五医院肿瘤科,福建漳州363000

出　　处：《中国医药科学》2013年第14期41-43,共3页China Medicine And Pharmacy

摘　　要：目的分析食管支架置入术联合三维适形放疗(3D-CRT)治疗中晚期食管癌的临床疗效。方法 29例中晚期食管癌患者前期进行支架置入解决吞咽困难,后期针对原发病灶实施3D-CRT治疗(治疗组),分析肿瘤局部控制率、生存率并与同期19例单纯支架治疗患者(对照组)进行对比研究。结果治疗组CR5例(17.24%),PR20例(68.97%),近期有效率(CR+PR)为86.21%。平均生存期为(13.13±1.00)个月,中位生存期为(12.50±1.08)个月,对照组平均生存期为(7.87±0.98)个月,中位生存期为(7.00±0.70)个月,两组生存率比较差异有统计学意义(P<0.05)。结论支架置入术结合放疗治疗晚期食管癌有利于改善患者生活质量,提高患者生存率,是晚期食管癌的一种有效治疗方法。Objective To evaluate the efficacy of esophageal stent inserting combined with three-dimensional eonformal radiotherapy（3D-CRT） in the treatment of locally advanced esophageal carcinoma. Methods Twentynine patients of advanced esophageal carcinoma were inserted stent to solve the esophageal stenosis first,and then were applied with 3D-CRT（treated group）.The efficacy and the survival rate were analyzed and correlated with 19 patients who treated with stent placement alone （control group）. Results In the study group,5 cases were observed as complete response （17.24%）,20 cases were partial response （68.97%）, the overall response rate was 86.21%.The mean survival time was（13.13 ±1.00）months,the median survival time was （12.50 ± 1.08） months, compared with（ 7.87 ± 0.98） and（7.00 ±0.70）months of the control group,giving a significant difference between the two groups （P 〈 0.05）. Conclusion The combination of stent placement and 3D-CRT improve the quality of life and survival rate markedly,it is an effective treatment for esophageal carcinoma.

关 键 词：食管癌 金属支架 放射疗法 

分 类 号：R735.1[医药卫生—肿瘤]