多药耐药基因1C3435T基因多态性对胃溃疡患者抗幽门螺杆菌治疗的影响  

Influence of multidrug resistance gene 1 C3435T genetic polymorphism on the eradication of gastric ulcer with Helicobacter pylori infection

作　　者：张宇光[1] 孙艳荪[3] 周晓初[1] 陈洁生[1] 陈东燕[3] 李健[2] 吴子刚[4] 

机构地区：[1]广州中医药大学附属深圳市中医院外一科,518033 [2]广州中医药大学附属深圳市中医院消化内科,518033 [3]北京大学深圳医院特诊病房 [4]北京大学深圳医院消化内科

出　　处：《中国医师进修杂志》2013年第19期4-6,共3页Chinese Journal of Postgraduates of Medicine

基　　金：基金项目：深圳市科技计划（200602026）

摘　　要：目的探讨多药耐药基因（MDR）IC3435T基因多态性对胃溃疡患者抗幽门螺杆菌（rio）治疗的影响。方法共采集Hp阳性的胃溃疡患者106例，按抽签法随机分成EAC组（埃索美拉唑20meg次、克拉霉素0．5eg次、阿莫西林1．0g/次，均2次，d）和0AC组（奥美拉唑20mg/g次、克拉霉素0．5g，次、阿莫西林1．0g/次，均2次／a），每组53例，进行为期1周的抗Hp治疗，治疗结束至少4周检测Hp；采用聚合酶链反应．限制性内切酶技术检测两组MDR1基因多态性，记录并分析MDR1C3435T基因多态性对抗Hp治疗的影响。结果EAC组Hp根除率为84．9％（45／53），与OAC组的77．4％（41／53）比较差异无统计学意义（P〉0．05），两组MDR1C3435T不同基因型间Hp根除率比较差异亦无统计学意义（P〉0．05）。携带TT型基因Hp根除率为66．7％（16／24），携带CT型基因为86．3％（44／51），携带CC型基因为83．9％（26，31），携带，TT型基因Hp根除率最低，差异有统计学意义（P〈0．05）。两组携带TT型基因患者Hp根除率均低于其他两种基因型，差异有统计学意义（P〈0．05）。结论MDR1C3435T基因多态性与胃溃疡患者Hp根除疗效有关，携带TT型基因患者Hp根除率低。Objective To study the influence of multidrug resistance gene （MDR）I C3435T genetic polymorphism on the eradication of gastric ulcer with Helicobacter pylori （Hp） infection. Methods A total of 106 gastric ulcer patients with positive Hp were randomly divided into two groups by lot with 53 cases each. One group was assigned with 20 mg esomeprazole, 0.5 g clarithromycin, 1.0 g amoxicillin twice one day（EAC group）, and the other group was assigned with 20 mg omerprazole, 0.5 g clarithromycin, 1.0 g amoxiciUin twice one day （OAC group ）. The therapy of two groups was one week. Hp was detected at least 4 weeks after the end of treatment. MDR1 C3435T genetic polymorphism was determined by polymerase chain reaction-restriction fragment length polymorphism assay. The influence of MDR1 C3435T genetic polymorphism on the eradication of Hp was recorded and analyzed. Results The Hp eradication rate was 84.9%（45/53） and 77.4%（41/53） in EAC group and OAC group,and there was no significant differencebetween two groups （P〉 0.05 ）. There was no significant difference in the Hp eradication rate in patients with different MDR1 C3435T genotypes in two groups （P 〉 0.05 ）. The Hp eradication rate was 66.7%（16/24）, 86.3%（44/51 ）, 83.9%（26/31 ） in TT, CT, CC genotype, and there was significant difference（P〈 0.05）. The Hp eradication rate in patients with Tr genotype was lower than that in patients with CT,CC genotype, and there was significant difference （P〈 0.05）. Conclusion There is significant relationship between the effect of gastric ulcer with Hp eradication and MDRI C3435T genetic polymorphism, and the Hp eradication rates of patients with Tr genotype are more lower.

关 键 词：P糖蛋白 基因型 胃溃疡 螺杆菌 幽门 奥美拉唑 

分 类 号：R573.1[医药卫生—消化系统]