Ki67在宫颈上皮内瘤变和鳞癌组织中表达及意义  

Expression of Ki67 in cervical squamous intraepithelial neoplasia and sc and their significance

作　　者：谢伟晗[1] 韩柏贞[1] 高清梅[1] 

机构地区：[1]潍坊市妇幼保健院妇科,山东潍坊261000

出　　处：《中国优生与遗传杂志》2013年第7期29-30,共2页Chinese Journal of Birth Health & Heredity

摘　　要：目的观察Ki67在不同的宫颈病变中的表达情况。方法采用免疫组织化学S-P检测法,检测宫颈组织石蜡包埋标本108例(LCIN22例、HCIN22例和SC64例)Ki67的蛋白表达状况。结果 Ki67抗原的表达强度从LCIN组、HCIN组到SC组逐渐增强,呈正相关(Gamma=0.391,P<0.01)。在SC组中,Ki67的阳性表达率与患者的年龄、组织学分级和临床分期均无相关性。结论随着病变级别的升高(从LCIN、HCIN到SC),Ki67的表达趋势是逐渐升高的,提示它可能在宫颈癌的发展的过程中起重要作用,可作为预测CIN转归的指标。Ki67,可能是宫颈癌早期诊断的重要标记物。Objective： To explore the role of Ki67 in oncogenesis progression of cervical cancer.Methods： SP method of immunochemistry was employed to investigate the expression of Ki67 in 108 cervical tissue paraffin blocks including 22 LCIN,22 HCIN and 64 SC.Results： Ki67 expression of intensity grows stronger from LCIN,HCIN and SC groups in means of positive relation（Gamma = 0.391,P 0.01）.The positive expression rate of Ki67 in SC group has no relations to age,tissue grade and clinical stage.Conclusion： The expression Ki67 is upregulated gradually,and correlated with pathological grade（LCIN,HCIN and SC）,which probably indicates the over expressions of Ki67 are associated with the development of cervical cancer,and they would be predict a biomarker of squeal of CIN.Ki67 could be a better biomarker for early diagnose of the cervical cancer.

关 键 词：宫颈上皮内瘤变 宫颈癌 KI67 

分 类 号：R737.33[医药卫生—肿瘤]