癫痫及癫痫性抑郁障碍患者血清细胞因子的变化研究  

Determination of Cytokines in Epilepsy and Depression Induced by Epilepsy and Clinical Significance

作　　者：蒋萍[1] 刘骅[1] 郑丽华[1] 

机构地区：[1]宜宾市第二人民医院神经内科,四川宜宾644000

出　　处：《成都中医药大学学报》2013年第2期69-71,共3页Journal of Chengdu University of Traditional Chinese Medicine

摘　　要：目的:探讨癫痫及癫痫性抑郁障碍患者的血清白细胞介素-2(IL-2)、白细胞介素-6(IL-6)和肿瘤坏死因子-α(TNF-α)的水平及意义。方法:应用放射免疫法检测70例癫痫患者和64例癫痫性抑郁障碍患者的血清IL-2、IL-6和TNF-α的水平,同时检测正常对照组70例。结果:癫痫组和癫痫性抑郁障碍组患者血清IL-2、IL-6和TNF-α水平明显高于正常对照组,差异有统计学意义(P<0.01),癫痫性抑郁障碍组患者血清IL-2、IL-6和TNF-α水平高于癫痫组,IL-2和IL-6水平差别有统计学意义(P<0.05),血清TNF-α水平差别无统计学意义(P>0.05);Pearson等级相关分显示血清IL-2与癫痫性抑郁严重程度呈正相关(rs:0.373,P<0.01),血清IL-6水平与癫痫性抑郁严重程度呈正相关(rs:0.2920,P<0.05),血清TNF-α水平与癫痫性抑郁严重程度无明显相关性(rs:0.062,P>0.05);Spearman相关分析显示不同程度癫痫性抑郁障碍血清IL-2和IL-6水平与Zung评分存在正相关性(P<0.05),即随着Zung评分的增加,血清IL-2和IL-6水平呈上升趋势,血清TNF-α水平与Zung评分无明显相关性(P>0.05)。结论:细胞因子水平的升高可能为癫痫及癫痫性抑郁障碍的发病机制之一。Objective： To investigate the level of serum interleukin-2（IL-2）,interleukin-6（IL-6）,tumor necrosis factor-α（TNF-α） in epileptic patients and epileptic patients with depression and the significance.Methods： IL-2,IL-6 and tumor necrosis factor alpha（TNF-α） in 70 epileptic patients,64 epileptic patients with depression and 70 controls were measured by radioimmunoassay.Results： The serum levels of IL-2,IL-6 and TNF-α in epileptic patients and epileptic patients with depression were significantly higher than those in the controls（P 0.01）.The serum levels of IL-2,IL-6 and TNF-α in epileptic patients with depressive disorder were higher than epilepsy patients,the serum levels of IL-2 and IL-6 difference was statistically significant（P 0.05）,the serum level of TNF-α difference was not statistically significant（P 0.05）;Through rank correlation analysis,degree of epileptic patients with depression was positive correlation with IL-2（rs： 0.373,P 0.01） and IL-6（rs： 0.2920,P 0.05）,degree of epileptic patients with depression was no significant correlation with TNF-α（rs： 0.062,P 0.05）;Through spearman correlation analysis,the score of Zung of epileptic patients with depression was positive correlation with IL-2 and IL-6（P 0.05）,in other words there was tendency that the serum levels of IL-2 and IL-6 iecreased follow the the score of Zung of epileptic patients with depression,the score of Zung of epileptic patients with depression was no significant correlation with TNF-α（P 0.05）.Conclusion： Cytokines may play a role in the pathogenesis of epileptic and epileptic depression.

关 键 词：癫痫 癫痫性抑郁障碍 细胞因子 

分 类 号：R742.1[医药卫生—神经病学与精神病学] R329.2[医药卫生—临床医学]