MAPK信号转导途径及与在成骨细胞中作用的研究进展  

The MAPK Signal Pathway and Effect in Osteoblast

作　　者：曲爱娜[1] 周慧芳[2] 

机构地区：[1]武警后勤学院附属医院实验动物中心,天津300162 [2]天津医科大学外科手术学教研室,天津300000

出　　处：《武警后勤学院学报（医学版）》2013年第6期567-570,共4页Journal of Logistics University of PAP（Medical Sciences）

摘　　要：丝裂原活化蛋白激酶(mitogen-activated protein kinase,MAPK)对于细胞的生长、分裂、分化和凋亡具有重要的调节作用。骨质疏松是一种严重危害人类健康和生活的疾病,具有发病率高特点。近年来的研究发现,MAPK信号通路在成骨细胞增值分化中起重要作用。本文对MAPK在成骨细胞中的作用进行简要综述。Mitogen-activated protein kinase （MAPK） plays an important role in the cell growth, division, differentiation and apoptosis. Osteoporosis has a serious hazard to human health, and its morbidity is very high. Recently, it has been shown in many reports that there is an important role in proliferation and differentiation of osteoblasts.This article reviews the effect of MAPK in osteoblasts.

关 键 词：信号转导 丝裂原活化蛋白激酶 成骨细胞 

分 类 号：R745.4[医药卫生—神经病学与精神病学]