止痛一号方联合羟苯磺酸钙与甲钴胺治疗三叉神经痛50例  

Effect of "No.1 Pain-relieving Formula" combined with Doxium Tablets and Mecobalamin for trigeminal neuralgia: a report of 50 cases

作　　者：刘云[1] 潘卫东[1] 杨硕慧[2] 俞晓飞[1] 孙燕[1] 王骏[1] 蔡定芳[1] 

机构地区：[1]上海中医药大学附属曙光医院脑病科,上海201203 [2]上海中医药大学附属曙光医院放射科,上海201203

出　　处：《上海中医药杂志》2013年第6期56-58,共3页Shanghai Journal of Traditional Chinese Medicine

基　　金：上海市科委"上海市浦江人才计划"项目(09PJ1409300)

摘　　要：目的从改善微循环角度评价止痛一号方联合羟苯磺酸钙与甲钴胺治疗三叉神经痛的临床疗效。方法将98例患者随机分为治疗组和对照组。治疗组50例予中药止痛一号方联合羟苯磺酸钙与甲钴胺;对照组48例予卡马西平加甲钴胺;两组疗程均为8周,观察临床疗效及VAS评分变化情况。结果治疗组、对照组总有效率分别为86.0%、68.8%,治疗组临床疗效优于对照组(P<0.05)。两组VAS评分在治疗后均明显下降(P<0.05),组间治疗后差异有统计学意义(P<0.05)。治疗组不良反应发生率为12.0%,明显低于对照组的31.25%(P<0.05)。结论止痛一号方联合羟苯磺酸钙与甲钴胺治疗三叉神经痛安全、有效。Objective To evaluate the clinical efficacy of ＂No.1 Pain-relieving Formula＂ combined with Doxium Tablets and Mecobalamin in treating trigeminal neuralgia（TN）.Methods Ninety-eight cases were randomized into two groups： treatment group in which 50 cases were treated by ＂No.1 Pain-relieving Formula＂ combined with Doxium Tablets and Mecobalamin,and control group in which 48 cases were treated by Carbamazepine and Mecobalamin,with the course of 8 weeks.The clinical efficacy and score of VAS were evaluated.Results The overall effective rate was86.0% in the treatment group and 68.8% in the control group,with significant difference between the two groups（P0.05）.After treatment,the scores of VAS in the two groups were markedly decreased（P0.05）,with significant difference between the two groups（P0.05）.The occurrence rate of adverse reaction was 12.0% in treatment group,which was markedly lower than the 31.25% of the control group（P0.05）.Conclusion ＂No.1 Pain-relieving Formula＂ combined with Doxium Tablets and Mecobalamin is safe and effective in the treatment of TN.

关 键 词：三叉神经痛 微循环改善 中西医结合疗法 止痛一号方 

分 类 号：R745.11[医药卫生—神经病学与精神病学]