Salusins及其心血管效应  

Salusins and Its Cardiovascular Effects

作　　者：任安经[1] 林丽[2] 严晓红[3] 袁文俊[2,4] 

机构地区：[1]第二军医大学病理生理学教研室,上海200433 [2]第二军医大学生理学教研室,上海200433 [3]武汉大学基础医学院生理学系,武汉430071 [4]宁夏医科大学基础医学院生理学系,银川750004

出　　处：《生理科学进展》2013年第3期164-168,共5页Progress in Physiological Sciences

基　　金：国家重点基础研究项目(2009CB521902);国家自然科学基金(31271221)资助课题

摘　　要：Salusins是一类新发现的心血管活性肽,包括由28个氨基酸组成的salusin-α和20个氨基酸组成的salusin-β。Salusins广泛分布于人和大鼠的多种组织和器官,具有降低血压、减慢心率、抑制心肌收缩、减轻心脏缺血损伤、促进心肌细胞肥大和血管平滑肌细胞增殖等一系列心血管效应。值得注意的是,作为由同一前体产生的两种多肽,salusin-α和salusin-β在动脉粥样硬化的发生发展中具有相反的作用。Salusins are newly discovered cardiovascular active peptides, including salusin-a and salusin-β, which are peptides containing 28 and 20 amino acids respectively. Salusins are widely distributed in tissuse and organs of human and rat, and have a series of cardiovascular effects, including lowering blood pressure, slowing down the heart rate, inhibiting myocardial contraction, reducing cardiac ischemic injury, and promoting hypertrophy of cardiomyocytes and proliferation of vascular smooth muscle cells. It is noteworthy to mention that salusin-α and salusin-β are polypeptides produced by the same precursor and play opposite roles in the development and progression of atherosclerosis.

关 键 词：salusins 心脏 血管 动脉粥样硬化 

分 类 号：R364[医药卫生—病理学]