Stathmin基因在乳腺癌组织中的表达及意义  

Expression of Stathmin protein and its significance in breast cancer

作　　者：汤红平[1] 黄犁[1] 黄新翼[1] 姜辉[1] 高慧军[1] 陈莹莹[1] 

机构地区：[1]南方医科大学附属深圳妇幼保健院病理科,广东深圳518028

出　　处：《蚌埠医学院学报》2013年第7期821-823,共3页Journal of Bengbu Medical College

摘　　要：目的:探讨Stathmin基因在乳腺癌中的表达及其与临床病理特征之间的关系。方法:应用免疫组织化学法,检测87例乳腺癌、20例乳腺良性病变及20例正常乳腺组织中Stathmin的表达情况,分析其表达与患者年龄、肿瘤大小、组织学分级、临床分期及淋巴结转移等临床病理特征之间的关系。结果:Stathmin蛋白在乳腺癌、乳腺良性病变及正常乳腺组织中的阳性率分别为83.9%、30.0%和25.0%,明显高于乳腺良性病变和正常乳腺组织中的阳性率(P<0.01)。Stathmin阳性率在乳腺癌的临床分期和区域淋巴结有无转移间差异均有统计学意义(P<0.05),而在患者年龄、肿瘤大小及组织学分级间差异均无统计学意义(P>0.05)。结论:Stathmin在乳腺癌组织中过表达,其表达在乳腺癌发生发展过程中可能起着一定作用,Stathmin可作为乳腺癌诊断及判断预后的一个潜在标志物。Objective：To explore the expression of Stathmin protein in human breast cancer and evaluate the relationship between the expression of Stathmin and clinicopathological characteristics of breast cancer. Methods ：The expression levels of Stathmin protein in 87 cases of breast cancer,20 cases of breast benign lesions and 20 cases normal breast tissue were investigated by immunohistochemical method. The relationships between the expression of Stathmin and patients＇ age ,tumor size, histological grade, clinical stage and lymph node metastasis of breast cancer were analyzed. Results ： The positive expression rates of Stathmin in breast cancer, breast benign lesions and normal breast tissue were 83.9% ,30.0% and 25.0% , respectively, the Stathmin expression in breast cancer was significantly higher than that in breast benign lesions and normal breast tissue（ P 〈 0.01 ）. The differences of Stathmin expression in different clinical stage and lymph node metastasis bad statistical significance （P 〈 0.05 ）, the differences of Stathmin expression in different patient＇s age, tumor size and histological grade had no statistical significance （ P 〉 0.05 ）. Conclusions ： Stathmin is overexpressed in breast cancer, which may play a certain role in its genesis and development. Stathmin can serve as a potential marker in the diagnosis and prognosis of breast cancer.

关 键 词：乳腺肿瘤 STATHMIN蛋白 免疫组织化学 

分 类 号：R737.9[医药卫生—肿瘤]