14例血管周上皮样细胞分化肿瘤临床病理分析  

Clinical and pathological features of perivascular epithelioid cell tumor:an analysis of 14 cases

作　　者：黄述斌[1] 李松梅[1] 王志强[1] 徐亮[1] 邢小翠[1] 王海平[1] 周爱娣[1] 

机构地区：[1]安徽省池州市人民医院,安徽池州247000

出　　处：《安徽医药》2013年第6期997-999,共3页Anhui Medical and Pharmaceutical Journal

摘　　要：目的探讨具有血管周上皮样细胞分化的肿瘤(tumors showing perivascular epithelioid cell differentiation,PEComa)临床病理特征及免疫表型。方法对14例PEComa进行组织学观察及免疫组化染色,并分析其临床病理学特征和免疫组织化学特点。结果 14例病例中,男性5例,女性9例,随访均无复发或转移,肿瘤可发生在身体许多部位,以肝脏和肾脏多见,多为实性界限较清楚肿块。特征性组织学特征是梭形或上皮样肿瘤细胞围绕血管生长,血管有厚壁和薄壁两种,伴有不等量的脂肪组织。免疫组化染色所有病例均表达HMB45和Melan-A,Ki-67阳性率低。结论 PEComa是一种少见的肿瘤,有其独特的组织学形态特征,免疫组化有助于辅助诊断。Objective To investigate the clinicopathologicl features and immunological phen0type of perivascular epithelioid cell tumor （PEComa）. Methods Histopathological examination and immunohistochemical assay were used to observe the characteristics of 14 ca- ses of PEComa. Results Among those patients 5 patients were males and 9 were females. No postoperative recurrence was found in all the patients. Tumors could occur in any organs of the body,but mostly in liver and kidney. Most of these tumors were encapsulated and solid. The growth of spindle and blent epithelioid cells around the blood vessels was typical histological change with various amount of ad- ipose tissues,the vessels having thin or thick walls. Immunohistochemical study revealed that all tumors were significantly expressed by HMIM5 and Melan-A,while the positive rate of Ki-67 was not high. Conclusion PEComa is a rare tumor,which has its unique histologi- cal morphological characteristics. Immunohistochemical detection may be helpful to diagnosis.

关 键 词：血管周上皮样细胞分化的肿瘤 临床病理学特征 免疫组织化学 

分 类 号：R730.2[医药卫生—肿瘤]