奥曲肽在手术治疗肿瘤性肠梗阻中的疗效研究  

Efficacy study of octreotide in surgical treatment of tumor ileus

作　　者：胡海军 李明伟[1,2] 郭春华 夏利刚[1,2] 潘凯 

机构地区：[1]暨南大学第二临床医学院 [2]深圳市人民医院胃肠外科,广东深圳518020

出　　处：《中国当代医药》2013年第20期106-107,共2页China Modern Medicine

摘　　要：目的观察奥曲肽持续泵入治疗肿瘤性肠梗阻的临床疗效。方法将采用手术治疗的肿瘤性肠梗阻患者50例随机分为两组,对照组(26例)采用常规治疗方法,包括禁食、鼻胃管胃肠减压、全肠外营养支持等;治疗组(24例)在常规治疗的基础上,给予奥曲肽治疗。观察两组患者的24 h胃肠减压量、保守治疗失败需急症手术率、切口感染率、预防性造口率和肠瘘率。结果治疗组24 h胃肠减压量、保守治疗失败需急症手术率、切口感染率、预防性造口率及肠瘘率与对照组比较,差异均有统计学意义(P<0.05)。结论奥曲肽持续泵入治疗急性肿瘤性肠梗阻是一种安全、有效的手段。Objective To observe the clinical efficacy of continuous infusion of octreotide in the treatment of tumor ileus. Methods 50 cases of patients with tumor ileus who received surgical treatment were divided into two groaps,the control group（26 cases） received conventional treatment,included fasting, nasogastric gastrointestinal decompression and total parenteral nutrition support;the treatment group （24 cases） received octreotide in addition to conventional treat- ment.The 24-hour gastrointestinal decompression amount,conservative treatment failure requiring emergency surgery rate,wound infection rate,preventive colostomy rate and intestinal fistula rate of the two groups were observed. Results Compared to the control group,the differences of the 24-hour gastrointestinal decompression amount decreased signifi- cantly,the conservative treatment failure requiring emergency surgery rate,wound infection rate,preventive colostomy rate and intestinal fistula rate in treatment group were statistically significant（P〈0.05）. Conclusion Continuous infusion of octreotide is a safe and effective means for the conservative treatment of acute intestinal tumor.

关 键 词：奥曲肽 持续泵入 肿瘤性肠梗阻 

分 类 号：R735[医药卫生—肿瘤]