抑郁症患者经颅多普勒检测的对照分析  

Analysis of Test results of Transcranial Doppler in Patients with Depression

作　　者：余晓仪[1] 郑洪波[2] 莫志标[3] 王燕萍[3] 刘榴[4] 

机构地区：[1]广州医科大学附属脑科医院,广东广州510370 [2]广州医科大学,广东广州510182 [3]广州市脑科医院经颅多普勒室,广东广州510370 [4]广州市脑科医院超声室,广东广州510370

出　　处：《现代生物医学进展》2013年第21期4103-4106,4063,共5页Progress in Modern Biomedicine

摘　　要：目的:分析并探讨抑郁症患者经颅多普勒(TCD)检测指标,为临床治疗提供借鉴。方法:选取我院2011年10月-2012年10月收治抑郁症患者120例,设为观察组,以同期健康正常人120例设为对照组,均行经颅多普勒检测,比较两组双侧大脑中动脉(MCA)、大脑前动脉(ACA)、大脑后动脉(PCA)、椎-基底动脉(VA-BA)等血流速度及搏动指数(PI)、阻力指数(RI)。结果:观察组患者双侧大脑中动脉(MCA)、大脑前动脉(ACA)及大脑后动脉(PCA)血流速度均明显高于对照组,而椎、基底动脉(VA-BA)血流速度明显低于对照组,组间比较差异显著(p<0.05);对照组和观察组患者双侧大脑中动脉(MCA)、大脑前动脉(ACA)、大脑后动脉(PCA)、椎-基底动脉(VA-BA)搏动指数(PI)、阻力指数(RI)均处于正常范围内(0.6-1.0);另外,根据HAMD量表观察组抑郁程度,随着抑郁程度增强,双侧大脑中动脉(MCA)、前动脉(ACA)及后动脉(PCA)的血流速度逐渐增大,上述各值差异具有统计学意义(p<0.05)。结论:经颅多普勒检测出抑郁症患者的脑血流较正常人脑血流显著加快,且与抑郁的严重程度相关联,经颅多普勒监测抑郁症患者的脑血流变化,可以作为抑郁症患者的常规检查,为临床的治疗及诊断提供线索。Objective： Analysis and study of transcranial Doppler in patients with depression（TCD） detection index,provides the reference for the clinical treatment of.Methods： In our hospital in 2011 October-2012 year in October of 120 patients with depression,as observation group,compared with 120 healthy men as control group,underwent transcranial Doppler detection,compared two groups of bilateral middle cerebral artery（MCA）,anterior cerebral artery（ACA）,posterior cerebral artery（PCA）,vertebral basilar artery（VA-BA）,blood flow velocity and pulsatility index.Results： The observation group of patients with bilateral middle cerebral artery（MCA）,anterior cerebral artery（ACA） and posterior cerebral artery（PCA） blood flow velocity was significantly higher than that of the control group,while the vertebrobasilar artery（VA-BA） blood flow velocity was significantly lower than that of the control group,the difference between groups was significant（p0.05）;the control group and the observation group artery patients with bilateral middle cerebral（MCA）,anterior cerebral artery（ACA）,posterior cerebral artery（PCA）,vertebrobasilar artery pulsatility index（VA-BA） were in the normal range（0.6-1.0）.Conclusion： Transcranial Doppler detection of cerebral blood flow in patients with depression than in normal human brain blood flow significantly slow,cerebral blood flow changes of transcranial Doppler monitoring of patients with depression,can be used as a routine examination in patients with depression,and provide the basis for the diagnosis and treatment of clinical.

关 键 词：抑郁症 经颅多普勒 脑血流速度 

分 类 号：R749.4[医药卫生—神经病学与精神病学] R445.1[医药卫生—临床医学]