核苷酸结合寡聚化结构域NOD样受体(NLRs)研究进展  

Advance in the Nucleotide Binding and Oligomerization Domain (NOD)-like Receptors(NLRs)

作　　者：李奕平[1] 王潇[1] 

机构地区：[1]内蒙古大学生命科学学院,呼和浩特010021

出　　处：《生物技术通报》2013年第7期36-40,共5页Biotechnology Bulletin

基　　金：内蒙古自然科学基金项目(2010MS0514);内蒙古大学校级创新训练计划项目(2012156)

摘　　要：先天免疫系统是防御微生物的第一道防线。最近几年,人们发现一种新的蛋白家族——核苷酸结合寡聚化结构域NOD样受体(NLRs),可以识别、抵御微生物病原体,在动物和植物体内的先天免疫中起重要作用。NLR蛋白激活后导致NF-κB,MAPK或半胱氨酸天冬氨酸酶的激活,从而介导炎症反应。对NLR家族及与之相关的炎症性疾病进行论述,并对NLR家族在炎症性疾病治疗的应用前景作展望。The innate immune system is the first line of defense against microorganisms, recent studies identified a new kind of protein, the nucleotide binding and oligomerization domain （NOD）-like receptors （NLRs） which can recognize and respond against pathogens, play an important role in the innate immune of the plant and animal. Activation of NLR proteins results in inflammatory responses mediated either by NF-KB, MAPK or Caspase-1 activation. The paper summarized the NLR family and the inflammatory diseases associated with it. The NLR family in the treatment of inflammatory diseases were also prospected.

关 键 词：先天免疫 NLRS NOD1 NOD2 炎症疾病 

分 类 号：R341[医药卫生—基础医学]