FoxM1、Cep55蛋白在基底细胞样型乳腺癌中的表达及临床意义  

Expression and clinical significance of FoxM1 and Cep55 protein in basal-like breast carcinoma

作　　者：马秋双[1] 张金库[1] 周炳娟[1] 赵文明[1] 赵亚飞[2] 

机构地区：[1]保定市第一中心医院病理科,071000 [2]保定市第一中医院骨科

出　　处：《中国医师进修杂志》2013年第20期7-10,共4页Chinese Journal of Postgraduates of Medicine

摘　　要：【摘要】目的探讨FoxM1和Cep55蛋白在基底细胞样型乳腺癌（BLBC）中的表达及临床意义。方法采用免疫组织化学方法检测66例BLBC及其癌旁正常乳腺组织、70例非BLBC组织中FoxM1和Cep55蛋白的表达情况及二者间的关系。结果BLBC、非BLBC及癌旁正常乳腺组织中FoxMl蛋白阳性表达率分别为77．3％（51／66）、60．0％（42／70）和13．6％（9／66），Cep55蛋白阳性表达率分别为74．2％（49／66）、57．1％（40／70）和16．7％（11／66），BLBC和非BLBC组织均明显高于癌旁正常乳腺组织，BLBC组织明显高于非BLBC组织，差异均有统计学意义（P〈0．05）。BLBC组织中FoxMl和Cep55蛋白阳性表达与腋窝淋巴结转移及TNM分期有关，差异均有统计学意义（P〈0．05）；而与年龄、绝经情况、肿瘤大小无关，差异均无统计学意义（P〉0．05）。Spearman相关分析结果显示，BLBC组织中FoxM1蛋白与Cep55蛋白表达呈正相关（r=0．259，P〈0．05）。结论FoxMl和Cep55蛋白可能参与了BLBC的发生、发展，并且FoxMl和Cep55蛋白可能有一定的协同作用。Objective To study the expression and clinical significance of FoxM1 and Cep55 protein in basal-like breast carcinoma （BLBC）. Methods The expression of FoxM1 and Cep55 protein in 66 cases of BLBC,70 cases of non-BLBC and 66 cases of normal adjacent breast tissue were detected by immunohistochemistry. Their relationship with the chnical pathological factors was analyzed. Results The positive rate of FoxM1 protein in BLBC,non-BLBC and normal adjacent breast tissue was 77.3% （51/66）, 60.0% （42/70） and 13.6% （ 9/66 ）, Cep55 protein was 74.2% （ 49/66 ）, 57.1% （40/70） and 16.7% （ 11/66 ）, respectively. BLBC and non-BLBC tissue were higher than normal adjacent breast tissue, and BLBC tissue was higher than non-BLBC,there was significant difference （P 〈0.05）. In BLBC tissue,the positive expression of FoxM1 and Cep55 protein correlated with lymph nodes metastasis and TNM staging （P 〈 0.05）,while did not correlate with age,menopause,tumor size （P 〉 0.05）. There was direct correlation between the positive expression of FoxM1 and Cep55 protein （r = 0.259,P 〈 0.05）. Conclusion FoxM1 and Cep55 protein may play an important role in the carcinogenesis and development of BLBC, and both of them have the synergistic effect.

关 键 词：乳腺肿瘤 FoxM1蛋白 Cep55蛋白 

分 类 号：R737.9[医药卫生—肿瘤]