慢性脑低灌注大鼠的侧支循环研究现状  

Research status of collateral circulation of chronic cerebral hypoperfusion in rats

作　　者：井珍[1] 张世军[1] 黄立安[1] 

机构地区：[1]暨南大学第一附属医院神经内科,广州510632

出　　处：《国际脑血管病杂志》2013年第6期477-480,共4页International Journal of Cerebrovascular Diseases

基　　金：国家自然科学基金（81271280）;广东省科技计划（21612428）

摘　　要：侧支循环可能是缺血性卒中的潜在治疗靶点，但针对改善侧支循环的治疗目前尚未得到可靠地临床验证。因此，首先在慢性脑低灌注动物模型中开展侧支循环研究具有重要的现实意义。文章对大鼠慢性脑低灌注模型制作方法、神经行为评价、脑灌注评定、侧支循环途径以及改善侧支循环的实验研究现状进行了综述。collateral circulation may be a potential therapeutic target for ischemic stroke. However, aiming at improving the treatment of collateral circulation, it has not yet got the reliable clinical validation now. Therefore, undergoing the study of collateral circulation first in the animal models of chronic cerebral hypoperfusion has important practical si^aificance. This article reviews the methods of rat chronic cerebral hypoperfusion models, neurobehavioral evaluation, cerebral perfusion assessment, collateral circulation pathways, and the experimental research status of improving collateral circtdation.

关 键 词：脑缺血 侧支循环 认知障碍 疾病模型 动物 大鼠 

分 类 号：R743[医药卫生—神经病学与精神病学]