白三烯A4水解酶基因多态性与缺血性脑卒中相关性  

THE RELATIONSHIP BETWEEN LEUKOTRIENE A4 GENE POLYMORPHISM AND CEREBRAL ISCHEMIC STROKE

作　　者：侯树刚[1] 孙瑛[1] 刘丽君[1] 周畅[1] 张晨[1] 

机构地区：[1]青岛大学医学院附属医院神经内科,山东青岛266003

出　　处：《齐鲁医学杂志》2013年第4期325-327,共3页Medical Journal of Qilu

基　　金：山东省自然科学基金资助项目(ZR2010HM061)

摘　　要：目的探讨白三烯A4水解酶(LTA4H)基因多态性与缺血性脑卒中(IS)的关系。方法采用病例-对照研究、聚合酶链反应-限制性片段长度多态性(PCR-RFLP)方法,检测380例IS病人和290例健康体检者(对照组)LTA4H-rs2660845位点的基因多态性。结果与对照组比较,IS组及其亚组的LTA4H-rs2660845基因型(AA、AG、GG)与等位基因(A、G)的分布频率差异无显著性(P>0.05)。结论 LTA4H-rs2660845基因多态性可能与IS的发病无关。Objective To explore the relationship between leukotriene A4 hydrolase （LTA4H） gene polymorphism and cerebral ischemic stroke （CIS）. Methods By employing a case control study, the LTA4H-rs2660845 gene polymorphism in 380 CIS patients and 290 healthy subjects were detected by using polymerase chain reaction-restriction fragment length polymorphism （PCR-RFLP）. Results Compared with the control group, the differences of distribution of LTA4H-rs2660845 genotype （AA, AG,GG） and allele frequencies（A,G） in CIS group and its subgroup were not significant （P〈0.05）. Conclusion The polymorphism of LTA4H-rs2660845 is unlikely to be involved in the development of CIS.

关 键 词：白三烯A4 脑血管意外 多态性 限制性片段长度 

分 类 号：R743[医药卫生—神经病学与精神病学]