基于马赫-曾德尔结构的相差表面等离子体共振传感器  

Phase Difference Surface Plasmon Resonance Sensor Based on Mach-Zehnder Configuration

作　　者：王弋嘉[1] 张崇磊[1] 王蓉[1] 朱思伟[2] 袁小聪[1] 

机构地区：[1]南开大学信息技术科学学院现代光学研究所,天津300071 [2]南开大学人民医院,天津300121

出　　处：《中国激光》2013年第7期209-213,共5页Chinese Journal of Lasers

基　　金：国家自然科学基金重点项目(61036013)

摘　　要：研究了一种基于马赫-曾德尔结构的相差表面等离子体共振(SPR)传感器系统。和传统的相位型SPR传感系统相比,该系统采用了p偏振光与s偏振光各自干涉后再相位相减来提取样品折射率信息的方法,从而显著降低了环境噪声的影响,提高了分辨率。系统最小可区分0.01°的相差,对应的分辨率为10-5 RIU(折射率单位)。应用此系统进行了生物大分子结合反应的测量,分辨率可达每平方微米160个IgG分子。研究结果为表面等离子体共振传感器在生物医学的应用提供了一定的参考。A phase-modulation surface plasmon resonance（SPR） sensor based on Mach-Zehnder configuration is presented and studied. Refractive index information of sample is extracted by phase substraction between the respective interference results of p-polarized and s-polarized light. Compared with the traditional phase-modulation SPR sensors, this design reduces the influence of environment noise and therefore greatly improves resolution. The system can distinguish 0.01° phase difference at least, which is equivalent to 10-5 RIU （refractive index unit）. This system is employed to detect the reaction of biological molecules, and a resolution as high as 160 moleculars （IgG） per square microns is obtained. This study provides a certain reference to phase-modulation SPR sensors in application of bio-medical research.

关 键 词：传感器 表面等离子体共振 相差 差分干涉 分辨率 

分 类 号：O436[机械工程—光学工程]