奥沙利铂联合多西他赛新辅助化疗对局部晚期宫颈鳞癌患者的近期疗效观察  

Short-term effect of docetaxel combined with oxaliplatin in neoadjuvant chemotherapy on locally advanced cervical squamous cell cancer

作　　者：赵敏 任娟红 吴维光[3] 葛俊丽[4] 谢婷婷[4] 綦春蕾[4] 于月成[4] 

机构地区：[1]武警工程大学医院妇产科,西安710086 [2]西安市东方医院 [3]武警后勤学院附属医院妇产科 [4]第四军医大学附属西京医院妇产科

出　　处：《山西医科大学学报》2013年第7期562-565,共4页Journal of Shanxi Medical University

摘　　要：目的探讨奥沙利铂联合多西他赛的新辅助化疗在局部晚期宫颈鳞癌治疗的应用价值。方法 52例局部晚期宫颈鳞癌患者,按照病情随机分为治疗组和对照组。治疗组27例接受奥沙利铂和多西他赛方案的新辅助化疗2个疗程后进行手术治疗,对照组25例仅接受手术治疗。评价治疗组患者的近期疗效和毒性反应,并比较两组患者术中及术后情况。结果治疗组27例患者,2例完全缓解,19例部分缓解,6例无效,临床总有效率为77.78%(21/27);手术后病理评价总有效率达85.19%(23/27)。并且化疗毒性反应轻,不良反应可以耐受。与对照组比较,治疗组术后病理宫旁及阴道切缘阳性率低(P<0.05),盆腔淋巴结转移率低(P<0.05),而两组间手术时间、术中出血量、尿管留置时间、并发症发生率均无明显差异(P>0.05)。结论应用奥沙利铂联合多西他赛化疗方案进行局部晚期宫颈癌的新辅助化疗,能缩小肿瘤体积,提高手术治疗效果,近期疗效显著。Objective To evaluate the value of docetaxel combined with oxaliplatin in neoadjuvant chemotherapy for locally advanced cervical squamous cell cancer. Methods Fifty-two patients with locally advanced cervical squamous cell cancer were enrolled and randomized into treatment group and control group.Twenty-seven cases in treatment group received neoadjuvant chemotherapy with docetaxel and oxaliplatin for 2 cycles and followed by radical hysterectomy and pelvic lymphadenectomy.The other 25 cases in control group were treated with surgery alone. Results After neoadjuvant chemotherapy,two cases got complete remission,nineteen cases got partly remission,and six cases got no remission.The total response rate of neoadjuvant chemotherapy was 77.78%（21/27）,and the pathological response rate was 85.19%（23/27）.The toxicities were weak and side effects were tolerable in treatment group.Compared with control group,the positive rates of parametrial and vagina edges in treatment group were significantly decreased（P0.05）,and the positive rate of pelvic lymph node metastasis was significantly decreased（P0.05）.There was no significant difference in operation time,blood loss,indwelling catheter time,and the incidence of complications between two groups（P0.05）. Conclusion The docetaxel combined with oxaliplatin in neoadjuvant chemotherapy for locally advanced cervical squamous cell cancer could reduce the tumor size and enhance effective of radical operation,which has good short-term effects.

关 键 词：宫颈癌 新辅助化疗 多西他赛 奥沙利铂 

分 类 号：R737.33[医药卫生—肿瘤]