抗抑郁药物对卒中后抑郁患者P300变化的循证医学评价  

EBM Analysis of P300 in Patients with Post-Stroke Depression

作　　者：徐军辉 沈莹[2] 陈正昕[3] 金卫东[3] 

机构地区：[1]新疆阿拉尔人民医院精神科,新疆阿拉尔843300 [2]浙江大学医学院,浙江杭州310010 [3]浙江省立同德医院浙江省精神卫生中心,浙江杭州310010

出　　处：《中国药物评价》2013年第3期155-158,共4页Chinese Journal of Drug Evaluation

摘　　要：目的:分析抗抑郁药物对卒中后抑郁患者P300的潜伏期和波幅的影响。方法:符合本分析入组标准的中国大陆发表的6项研究Meta分析。结果:抗抑郁药物可明显缩短卒中后抑郁患者P300的潜伏期(WMD=41.40,95%CI:27.36.8～40.0,Z=17.66,P<0.01),提高P300的波幅(WMD=-1.89,95%CI:-2.28～-1.49,Z=9.38,P<0.01);与常规治疗在不用抗抑郁治疗的情况下,抗抑郁药物与对照组相比,P300潜伏期明显缩短(WMD=30.78,95%CI:26.12～35.44,Z=12.59,P<0.01),P300波幅明显提高(WMD=1.31,95%CI:0.94～1.69,Z=6.85,P<0.01)。结论:抗抑郁药物对卒中后抑郁症患者P300的潜伏期明显延长,波幅明显降低,提示抗抑郁药物可以改善与卒中后抑郁相关的认知功能的生物学指标。Objective： To assess the change of P300 in patients with post-stroke depression. Methods： 6 studies published meeting our criteria were analyzed by evidence-based medicine. Results： The P300 latency in patients with post-stroke depression was significant shorter and higher after treatment with antidepressants（ WMD=41. 40,95% CI： 27. 36. 8～40. 0,Z=17. 66,P＆lt;0. 01,WMD=-1. 89, 95% CI： - 2. 28～- 1. 49,Z=9. 38,P＆lt;0. 01） ） . The latency was shorter and amplitude was higher in patients treated by antidepres- sants than that in patients treated by no antidepressants of routine therapy（ WMD=30. 78,95% CI： 26. 12～35. 44,Z=12. 59,P＆lt;0. 01, WMD=1. 31,95% CI： 0. 94～1. 69,Z=6. 85,P＆lt;0. 01） . Conclusion： The depressants can shorted P300 latency and decreased ampli- tude that were biological index associated with impaired cognitive function.

关 键 词：卒中后抑郁 抗抑郁药物 P300 潜伏期 波幅 Meta分析 

分 类 号：R749.1[医药卫生—神经病学与精神病学] R743.3[医药卫生—临床医学]