限制性液体复苏对出血未控制性休克大鼠肠屏障功能障碍的保护作用  

Protective effects of limited fluid resuscitation on intestinal barrier dysfunction in rats with uncontrolled hemorrhagic shock*

作　　者：张兴文[1] 刘晓亮[1] 刘智玲[1] 李想[1] 廖文章[1] 

机构地区：[1]湖南省人民医院,湖南长沙410005

出　　处：《中国现代医学杂志》2013年第15期11-14,共4页China Journal of Modern Medicine

基　　金：湖南省科学技术厅课题资金(No:2010FJ3145);湖南省人民医院仁术基金联合资助(湘人医院字[2011]54)

摘　　要：目的探讨限制性液体复苏对出血未控制性休克(UHS)大鼠肠屏障功能障碍的保护作用。方法将36只SD大鼠均建立UHS模型,随机分成对照组(A组)、限制性复苏组(B组)、积极复苏组(C组)。模拟创伤救治过程,A组大鼠未行液体复苏,B、C组进行不同方法液体复苏,2 h后检测门静脉血D-乳酸(D-LA)、内毒素(ET)浓度,小肠黏膜组织病理学评分。结果 A组血D-LA及ET浓度、小肠病理组织学评分均高于B、C组,B组各指标明显低于C组。结论限制性液体复苏较积极复苏更能显著减轻实验性UHS大鼠门静脉血D-LA和ET浓度,减少肠黏膜损伤,可能对改善UHS大鼠肠屏障功能障碍更有益。【Objective】To study the protective effects of limited fluid resuscitation on intestinal barrier dysfunction in rat with uncontrolled hemorrhagic shock.【Methods】Model of 36 SD rat with uncontrolled hemorrhagic shock were set up and divided randomly into 3 groups：（A） control group,（B） limited fluid resuscitation group,（C） aggressive fluid resuscitation group.Fluid resuscitation was not used in A group,while different measures of fluid resuscitation in B and C group,all of rats were measured the concentration of D-lactate（D-LA） and endotoxin（ET） in portal vein blood,to evaluate histopathology scoring of Intestinal mucosal all of rats after 3 h.【Results】The concentration of D-LA and ET and histopathology scoring of A group is higher significantly than B and C group,and B group is lighter than C group.【Conclusion】The limited fluid resuscitation reduce significantly the concentration of D-LA and ET in portal vein blood in the UHS group rats,decrease the damage of intestinal mucosa,and it is beneficial for improvement of Intestinal barrier dysfunction in rats with UHS.

关 键 词：限制性液体复苏 积极液体复苏 出血未控制性休克 肠屏障功能障碍 

分 类 号：R57[医药卫生—消化系统]