进展期胃癌患者新辅助化疗及术后血清Her-2/neuECD水平变化  

Changes of Serum Her-2/neu ECD Levels of Pre-and Post-Neoadjuvant Chemotherapy and Surgery in Patients with Advanced Gastric Cancer

作　　者：赵国栋[1,2] 王绥能[1,2] 谢权[1,2] 彭勃[1,2] 

机构地区：[1]海口市人民医院 [2]中南大学湘雅海口医院胃肠外科,海南海口570208

出　　处：《中国现代医学杂志》2013年第15期70-72,共3页China Journal of Modern Medicine

摘　　要：目的探讨进展期胃癌患者行新辅助化疗及手术后血清Her-2/neu ECD水平的变化及临床意义。方法采用双抗体夹心ELISA法检测海口市人民医院胃肠外科2011年2月～2012年6月42例进展期胃癌患者在新辅助化疗及手术前后血清Her-2/neu ECD水平,并统计根治手术率,进行统计学分析。结果 42例进展期胃癌患者行新辅助化疗后,血清Her-2/neu/neu ECD水平57.14%(24/42)下降,33.33%(14/42)未变化,9.52%(4/42)升高;化疗后血清Her-2/neu ECD水平下降组根治性切除率75.0%(18/24),化疗后血清Her-2/neu ECD水平升高、不变组根治性切除率44.44%(8/18),组间差异有显著性(P<0.05);而且根治性手术后患者与姑息术后患者血清Her-2/neu ECD水平下降率比较(分别为80.77%、31.25%),组间差异有显著性(P<0.05)。结论动态检测进展期胃癌患者新辅助化疗及手术前后血清Her-2/neu ECD水平变化对判断化疗、手术疗效及预后具有一定的临床意义。【Objective】To evaluate the clinical implication of variations in serum Her-2/neu extracellular domain（ECD） levels before and after treatment of advanced gastric cancer patients.【Methods】Serum Her-2/neu ECD levels of 42 advanced gastric cancer patients before and after neoadjuvant chemotherapy or surgery were assayed by enzyme-linked immunosorbent assay（ELISA）.【Results】After neoadjuvant chemotherapy,24/42（57.14%） of serum Her-2/neu ECD levels in advanced gastric cancer patients were ruduced,14/42（33.33%） were no changed,and 4/42（9.52%） were risen;significant different rates of radical operation were found between the patients with ruduce levels of serum Her-2/neu ECD（75.0%,18/24） and the others（44.44%,8/18）,and P〈 0.05.80.77% of the serum Her-2/neu ECD levels in the patients with radical operation were reduced,and only 31.25% of the leves in the patients with palliative operation were reduced,showing significant difference between the two groups（P〈 0.05）.【Conclusion】Kinetic monitoring of the changes of serum Her-2/neu ECD levels in advanced gastric cancer patients may represent a valuable tool for evaluating clinical response to neoadjuvant chemotherapy and surgery.

关 键 词：血清Her-2 neuECD 进展期胃癌 新辅助化疗 手术 ELISA 

分 类 号：R735.2[医药卫生—肿瘤]