冠心Ⅱ号方不同组分配伍对丹参素、阿魏酸在犬体内药代动力学的影响  

Study on Pharmacokinetics of Ferulic Acid and Danshensu in GuanxinⅡ by Combination with Different Drugs

作　　者：吕锡亮 李寅超[2] 何永侠[2] 谷艳[2] 彭娟[3] 范斌[3] 

机构地区：[1]河南省职工医院,郑州450002 [2]郑州大学药学院,郑州450001 [3]中国中医科学院中药研究所,北京100700

出　　处：《中国实验方剂学杂志》2013年第14期164-168,共5页Chinese Journal of Experimental Traditional Medical Formulae

摘　　要：目的:比较冠心Ⅱ号方不同配伍组丹参素、阿魏酸的药代动力学,揭示不同配伍对两成分体内过程的影响规律。方法:Beagle犬灌服冠心Ⅱ号各配伍方:①全方有效组分重组方;②全方中活血药有效组分重组方;③全方中理气药有效组分重组方;④全方中丹参有效组分;⑤全方中川芎有效组分。应用液-质联用(LC-MS/MS)法检测犬血浆中丹参素、阿魏酸含量,利用药代动力学软件DAS 2.0计算药代动力学参数,并比较组间差异。结果:与含丹参的其他两组比较,全方有效组分组丹参素的峰浓度(Cmax)和药-时曲线下面积(AUC)有增高趋势;与含川芎的其他两组比较,全方有效组分重组方组阿魏酸的清除率(CL)有降低趋势,表观分布容积(V)有增高趋势,但均无统计学意义。结论:Beagle犬灌服冠心Ⅱ号有效组分不同配伍对药效成分丹参素和阿魏酸的药代动力学过程基本一致。Objective： To compare pharmacokinetics of danshensu（DSS） and ferulic acid（FA） in different combinations to GuanxinⅡ,and to reveal the effect of the combination to GuanxinⅡ on the process in vivo of the two main effective components.Method： Beagle dogs were administrated orally with Guanxin Ⅱ in combination with different drugs： total extraction recombination,part extraction recombination propitious to blood,danshen extraction recombination,part extraction recombination propitious to breath,ligusticum wallichii extraction recombination.The plasma concentration of DSS and FA were assayed by LC-MS / MS after administration.the pharmacokinetic parameters were estimated by DAS 2.0 phamacokinetic software edited by SUN Rui-yuan,and then to compare pharmacokinetic parameters within different groups by statistic software SPSS 10.0.Result： The statistic results have showed that the pharmacokinetics of combination with different drugs to Guanxin Ⅱ have no significant difference,but the tendency.Conclusion： The process of danshensu and ferulic acid in vivo（Beagle dogs） are not significantly different.

关 键 词：冠心Ⅱ号 药代动力学 配伍 丹参素 阿魏酸 

分 类 号：R285.5[医药卫生—中药学]