醒脑静注射液对急性脑梗死患者血清PD-ECGF表达的干预作用  

Effects of Xingnaojing Injection on Expression of Platelet Derived Endothelial Cell Growth Factor in Patients with Acute Cerebral Infarction

作　　者：张晓玲 翟丽萍 官俏兵 杜瑛媛 钱淑霞 

机构地区：[1]嘉兴市第二医院神经内科,浙江嘉兴314000

出　　处：《中华中医药学刊》2013年第7期1579-1581,共3页Chinese Archives of Traditional Chinese Medicine

基　　金：浙江省中医药科学研究基金资助项目(20102B147)

摘　　要：目的:探讨急性脑梗死患者血清血小板衍生内皮细胞生长因子(PD-ECGF)的动态变化和醒脑静注射液的干预作用。方法:63例急性脑梗死患者随机分为醒脑静注射液治疗组32例和常规治疗对照组31例,另设立健康对照组60组。两组急性脑梗死患者均给予常规的抗血小板、他汀类药物治疗,治疗组在此基础上加用醒脑静注射液每天20 mL静滴,14 d为1个疗程。采用双抗体夹心酶联免疫吸附法(ELISA)动态测定63例急性脑梗死患者在发病后第1、3、7、14 d时血清PD-ECGF浓度,同时记录63例急性脑梗死患者入院时和治疗14 d后的梗死灶体积,并在治疗前和治疗后14 d后进行美国国立卫生院神经功能缺损评分(NIHSS评分)。结果:和健康对照组比较,63例急性脑梗死患者在中风后1、3、7、14 d各时间点的血清PD-ECGF浓度均明显增高,差异有统计学意义(P<0.05),急性期脑梗死患者的PD-ECGF浓度在中风后3 d达高峰,在中风后14 d维持增高;加用醒脑静注射液干预的治疗组血清PD-ECGF浓度在中风后第3、7、14 d明显高于常规治疗的对照组,差异有统计学意义(P<0.05);应用醒脑静注射液干预治疗14 d后,治疗组平均梗死灶体积小于常规治疗对照组,差异有统计学意义(P<0.05),14 d后治疗组NIHSS评分虽优于对照组,但两组差异未达统计学意义(P>0.05)。结论:急性脑梗死后血清PD-ECGF浓度有动态增高,醒脑静注射液能促进PD-ECGF的产生,参与新生血管形成,有望提高临床疗效。Objective：To observe the dynamic changes of platelet derived endothelial cell growth factor（PD-ECGF）in patients with acute cerebral infarction,and to explore the effects of Xingnaojing Injection on them.Methods：63 patients with acute cerebral infarction were randomly divided into Xingnaojing treatment group（experimental group,n=32） and routine treatment group（n=31）.Patients of both groups were treated with anti-platelet aggregation and stating,and patients in experimental group were given additional Xingnaojing Injection（20 mL,vd,qd） for 14 days.Serum concentrations of PD-ECGF were measured by double antibody sandwich ELISA on 1st,3rd,7th and 14th day after the onset of stroke.Meanwhile,volumes of infarction and scores of national institutes of health stroke scale（NIHSS）were recorded,both on admission and on day 14.In addition,sixty health individuals were selected as normal controls.Results：The serum concentrations of PD-ECGF in patients with acute cerebral infarction on day 1,3,7 and 14 were obviously increased,which reached to the climax on day 3 and maintained a high level in 14 days,and the differences were statistically significant compared with normal controls（P〈0.05）.The serum concentrations of PD-ECGF in experimental group on day 3,7 and 14 were significantly higher than those of routine treatment group（P〈0.05）.After treatment for 14 days,the mean volume of infarction in experimental group was obviously smaller than that of routine treatment group（P〈0.05）,and its NIHSS score was better as well,but the difference between two groups had no statistical significance（P〈0.05）.Conclusions：The serum concentration of PD-ECGF rises dynamically after occurrence of infarction.Xingnaojing Injection could promote the production of PD-ECGF and participate in angiogenesis,which is expected to improve the therapeutic effect.

关 键 词：急性脑梗死 血小板衍生内皮细胞生长因子 醒脑静注射液 

分 类 号：R743.33[医药卫生—神经病学与精神病学]