超微粉碎对黄芩粉体学性质的影响  

Influence of Superfine Grinding on Micromeritic Properties of Scutellaria baicalensis

作　　者：王念明[1] 张定堃[1] 杨明[1,2] 秦春凤[1] 韩丽[1] 苏柘僮[1] 郭治平 

机构地区：[1]成都中医药大学/中药资源系统研究与开发利用国家重点实验室培育基地,四川成都611137 [2]江西中医学院/现代中药制剂教育部重点实验室,江西南昌330004 [3]四川厚德医药科技有限公司,四川成都611731

出　　处：《中药材》2013年第4期640-644,共5页Journal of Chinese Medicinal Materials

基　　金：四川省重大产业技术创新专项项目(2011ZY00299)

摘　　要：目的:研究黄芩药材不同粒径的粉体学差异,为黄芩超微粉体的直接使用和作为中药制剂原料的使用提供依据。方法:制备4种不同粒径的黄芩粉体,从粒度及分布、比表面积与孔隙度、润湿性、休止角与松密度、吸湿性、微观形态、红外光谱、HPLC指纹图谱等方面评价4种粉体的粉体学差异。结果:随着黄芩药材粒径的减小,粉体粒度、松密度减小,比表面积与孔隙度、接触角增大,休止角先增后减,吸湿性增强;红外光谱与HPLC指纹图谱显示在一定时间内,超微粉碎黄芩药材并未引起化学组成成分与分子结构的改变。结论:不同粒径的黄芩药材,具有不同的性质,综合评价选择微粉Ⅲ为较优粒径。Objective ： To study the micromeritic properties of different particle size of ScuteUaria baicalensis and provide a basis for being directly used or as raw material of Chinese herba preparation. Methods：Size distribution, surface area and pore volume, contact angle, angle of repose and bulk density, moisture absorption, micromorphology, Infrared spectrum, HPLC fingerprint were used to evaluate the differences of micromeritic properties of 4 kinds of Scutellaria baicalensis superfine grinding. Results ： With the particle size of powders decreased, size distribution and bulk density decreased, the surface area and pore volume, contact angle and moisture absorption increased, angle of repose first increased and then decreased. Infrared spectrum and HPLC fingerprint showed no change of chemical composition of Scutellaria baicalensis. Conclusion： Different particle size of Scutellaria baicalensis leads to the differences of micromeritic properties. Superfine grinding m is determined as a better particle size.

关 键 词：黄芩 超微粉碎 粉体学性质 

分 类 号：R283.6[医药卫生—中药学]