人乳头瘤病毒16及18型E6与p53表达的关系  

The Relationship Between Human Papillomavirus Types 16,18 E6 and p53 Expression in Cervical Carcinoma

作　　者：徐耀先[1] 陈德基[1] 唐志佼[1] 解梦霞[1] 李蓓芸[1] 赵斌[1] 

机构地区：[1]湖北医科大学基础医学院,武汉430071

出　　处：《武汉大学学报（自然科学版）》2000年第4期500-504,共5页Journal of Wuhan University(Natural Science Edition)

基　　金：湖北省科学技术厅科研攻关基金!( 992 P12 0 9)

摘　　要：采用 SP免疫组织化学方法 ,比较了 6 8例宫颈癌组织中 HPV- 16、18E6和 p5 3蛋白的表达及其相互关系 .结果表明 ,6 8例宫颈癌中有 6 0例 HPV - 16、18E6蛋白和 17例 p5 3蛋白呈阳性表达 ,阳性率分别为 88.2 %和2 5 .0 % ;在 5 9例 HPV- 16、18E6蛋白过度表达的宫颈癌中有 5 4例 p5 3蛋白为阴性或弱阳性表达 ,二者呈负相关(P <0 .0 1) .p5 3蛋白阳性表达与组织学类型有关 ,其阳性率在宫颈腺癌中为 83.3%和宫颈鳞癌中为 17.2 % ,差异有极显著意义 (P <0 .0 1) .p5 3蛋白阳性表达随着临床分期上升而增高 .Immunohistochemistry SP method was used to study the relation between HPV types 16,18 E6 and p53 protein expression in 68 cases of cervical carcinomas. The results show HPV\|16,18 E6 and p53 protein positive expression were detected in 60 and 17 of 68 cervical carcinomas, positive rates of HPV\|16,18 E6, p53 protein were 88.2% and 25.0% respectively; overexpression of HPV\|16,18 E6 protein were revealed in 59 cases of cervical carcinomas with p53 negative and poor positive expression in 54 cases, the both showed a negative corretation(P<0.01). Expression of p53 was associated with histological types, its positive rate was 83.3% in adenocarcinoma and 17.2% in squamous cell carcinoma, there was a significant difference between adenocarcinoma and squamous cell carcinoma(P<0.01).Positive expression of p53 was higher as clinical stage increased(P<0.01).

关 键 词：宫颈癌 人乳头瘤病毒 E6蛋白 P53蛋白 病因 

分 类 号：R737.300.2[医药卫生—肿瘤]