Targeted therapy: tailoring cancer treatment  

作　　者：Min Yan Quentin Qiang Liu 

机构地区：[1]State Key Laboratory of Oncology in South China [2]Research Department,Sun Yat-sen University Cancer Center [3]Institute of Cancer Stem Cell, Cancer Center, Dalian Medical University

出　　处：《Chinese Journal of Cancer》2013年第7期363-364,共2页

摘　　要：Targeted therapies include small-molecule inhibitors and monoclonal antibodies, have made treatment more tumor-specific and less toxic, and have opened new possibilities for tailoring cancer treatment. Nevertheless, there remain several challenges to targeted therapies, including molecular identification, drug resistance, and exploring reliable biomarkers. Here, we present several selected signaling pathways and molecular targets involved in human cancers including Aurora kinases, PI3K/mTOR signaling, FOXO-FOXM1 axis, and MDM2/MDM4-p53 interaction. Understanding the molecular mechanisms for tumorigenesis and development of drug resistance will provide new insights into drug discovery and design of therapeutic strategies for targeted therapies.Targeted therapies include small-molecule inhibitors and monoclonal antibodies, have made treatment more tumor-specific and less toxic, and have opened new possibilities for tailoring cancer treatment. Nevertheless, there remain several challenges to targeted therapies, including molecular identification, drug resistance, and exploring reliable biomarkers. Here, we present several selected signaling pathways and molecular targets involved in human cancers including Aurora kinases, PI3K/mTOR signaling, FOXO-FOXM1 axis, and MDM2/MDM4-p53 interaction. Understanding the molecular mechanisms for tumorigenesis and development of drug resistance will provide new insights into drug discovery and design of therapeutic strategies for targeted therapies.

关 键 词：癌症治疗 靶向治疗 剪裁 单克隆抗体 生物标志物 分子鉴定 信号通路 分子机制 

分 类 号：R730.5[医药卫生—肿瘤]