糖尿病视网膜病变患者血清转化生长因子β水平研究  

Serum transforming growth factor-β levels in patients with diabetic retinopathy

作　　者：罗大卫[1] 郑志[1] 刘堃[1] 朱弼珺[1] 夏欣[1] 许迅[1] 邹海东[1] 

机构地区：[1]上海交通大学附属第一人民医院眼科,上海200080

出　　处：《上海交通大学学报（医学版）》2013年第7期990-992,共3页Journal of Shanghai Jiao tong University:Medical Science

基　　金：上海市眼底病重点实验室开放课题基金(07Z22911)~~

摘　　要：目的探讨糖尿病视网膜病变患者血清转化生长因子β(TGF-β)水平变化。方法 72例糖尿病患者分为增生性糖尿病视网膜病变组(PDR组,n=15)、非增生性糖尿病视网膜病变组(NPDR组,n=32)和无糖尿病视网膜病变组(NDR组,n=25);以45名体检健康者作为正常对照组。采用酶联免疫吸附法测定各组血清TGF-β水平。结果糖尿病患者TGF-β水平显著高于正常对照组(P<0.01),PDR组血清TGF-β水平显著高于NPDR组和NDR组(P<0.05)。结论 TGF-β水平与糖尿病视网膜病变的病变程度密切相关。Objective To investigate the serum transforming growth factor-β （TGF-β） levels in patients with diabetic retinopathy （DR）. Methods Seventy-two patients with diabetes were selected, including 15 patients with proliferative diabetic retinopathy （PDR group）, 32 patients with non-proliferative diabetic retinopathy （NPDR group） and 25 patients with non-diabetic retinopathy group （NDR group）. Besides, 45 healthy people were served as normal control group. The serum TGF-β levels were detected by ELISA. Results Serum TGF-β levels in groups with diabetes were significantly higher than that in normal control group （P 〈 0. 01）. Serum TGF-13 level in PDR group was significantly higher than those in NPDR group and NDR group （P 〈 0.05）. Conclusion Serum TGF-β level is associated with the severity of diabetic retinopathy.

关 键 词：糖尿病视网膜病变 转化生长因子Β 增生性视网膜病变 

分 类 号：R774.1[医药卫生—眼科]