早期低位直肠癌局部切除术后辅助放疗疗效分析  

Effect of Local Excision and Postoperative Radiotherapy on Patients with Early Distal Rectal Cancer

作　　者：张亚军[1] 张雷[1] 李文海[1] 段诗苗[1] 王亚国[1] 汪庚明[1] 徐洪波[1] 孙谦[1] 周育夫[1] 

机构地区：[1]蚌埠医学院第一附属医院肿瘤放疗科,安徽省蚌埠市233004

出　　处：《中华全科医学》2013年第9期1346-1348,共3页Chinese Journal of General Practice

摘　　要：目的探讨早期低位直肠癌局部切除术后加与不加放疗的疗效。方法回顾性分析2002年1月-2007年12月间进行局部切除术的56例早期低位直肠癌患者资料,其中29例为术后放疗同步给予氟尿嘧啶为基础的化疗。采用Kaplan-Meier进行生存分析,差异性检验采用Log rank法,组间比较采用χ2检验。结果 5年无病生存率局部切除术组和局部切除术联合放疗组分别为66.7%和89.7%,两组之间差异有统计学意义(χ2=4.469,P=0.035)。局部切除术组的5年局部复发率和5年总生存率为25.9%和74.1%,局部切除术联合放疗组为6.9%和93.1%,两组接近有统计学意义水平(χ2=3.75,P=0.053;χ2=3.638,P=0.056)。结论对于早期低位直肠癌,局部切除术联合辅助放疗是一个可供选择和可行的治疗技术。Objective To evaluate the outcome followed local excision with or without postoperative radiotherapy in patients with early distal rectal cancer. Methods Fifty-six patients with early distal rectal cancer undergoing local excision from Jan. 2002 to Dec. 2007 were analyzed retrospectively. 29 cases of them received postoperative radiotherapy ＋ 5-Fu-based ehemothera- py. The survival rates were estimated by Kaplan-Meier Method,and comparisons were made by the Log rank test. Results The 5- year rates of disease-fi＇ee survival were 66.7% in local excision group and 89.7% in local excision with radiotherapy group,the difference was statistically significant（ X2 =4. 469 ,P =0. 035 ）. The 5-year rates of local recurrence and the 5-year rates of overall survival were 25.9% and 74.1% in local excision group and 6.9% and 93.1% in local excision with radiotherapy group,re- spectively. The differences were approached statistical significant（ X2 = 3.75, P = 0. 053;X2 = 3. 638, P = 0. 056 ）. Conclusion The local excision followed adjuvant radiotherapy is an alternative and feasible technique for early distal rectal cancer.

关 键 词：直肠癌 局部切除术 放射治疗 

分 类 号：R735.37[医药卫生—肿瘤] R730.55[医药卫生—临床医学]