文拉法辛与氟西汀治疗抑郁症的对照研究  

The Comparison Study between Venlafaxine and Fluoxetine in the Treatment of Depression

作　　者：毛红岩[1] 陈长浩[1] 徐莉莎[1] 

机构地区：[1]安徽省宿州市第二人民医院精神科,234000

出　　处：《中华全科医学》2013年第9期1361-1362,共2页Chinese Journal of General Practice

摘　　要：目的比较文拉法辛与氟西汀治疗抑郁症的临床疗效和安全性。方法将70例抑郁症患者随机分为文拉法辛组(34例)和氟西汀组(36例),疗程为6周。治疗前后采用汉密尔顿抑郁量表17项(HAMD)和副反应量表(TESS)为评价工具评定疗效和不良反应。结果治疗6周后,文拉法辛组有效率为85.3%;氟西汀组有效率为83.3%;两组比较差异无统计学意义(P>0.05)。但文拉法辛组在HAMD量表减分值方面,第1周末、第2周末比氟西汀组下降更显著(P<0.01),其它时点评分差异均无统计学意义(P均>0.05);两组不良反应均轻微,发生率及TESS评分差异均无统计学意义(P>0.05)。结论文拉法辛治疗抑郁症疗效确切,安全性好,且起效快。Objective To explore the efficacy and side effects of the venlafaxine and fluoxetine in the treatment of depres- sion. Methods 70 patients with depression were randomly assigned to venlafaxine group and fluoxetine group. The patients were treated for 6 weeks. The efficacy was evaluated with Hamilton depression scale（HAMD） ,and the side effects were evaluated with treatments emergent symptoms scale （TESS）. Results Total effective rates were 85.3 % in the venlafaxine group and 83.3 % in the fluoxetine group ,the total efficacies of both groups were equivalent（ P 〉 0.05 ）. The HAMD scores lowered more significantly in the venlafaxine group than in the fluoxetine group at the end of the 1st and 2nd week. Adverse reactions of both groups were mild and there were no significant difference in incidences and TESS scores （ P 〉 0.05 ）. Conclusion Venlafaxine was effective, with fast onset of action and minor adverse reactions in treatment of depression.

关 键 词：文拉法辛 氟西汀 抑郁症 

分 类 号：R749.42[医药卫生—神经病学与精神病学] R971.43[医药卫生—临床医学]