Ki-67和p53在三阴性乳腺癌中的表达和意义  

Expression and Significance of Ki-67 and p53 in Tripie-Negative Breast Cancer

作　　者：杜华劲[1] 张月君[1] 周彩云[1] 

机构地区：[1]安徽省滁州市第一人民医院普外科,239000

出　　处：《中华全科医学》2013年第9期1393-1395,共3页Chinese Journal of General Practice

摘　　要：目的研究三阴乳腺癌(tripie negative breastcancera,TNBC)中Ki-67与p53的表达和意义,并探讨其与常规临床病理预后指标之间的关系。方法应用免疫方法检测58例三阴性乳腺癌中Ki-67和p53的表达,并分析它们与三阴性乳腺癌患者的年龄、肿瘤的TMN分期等关系。结果 Ki-67和p53在三阴性乳腺癌组的表达显著高于非三阴性乳腺癌(NTNBC)组(P<0.05)。Ki-67的表达与年龄、绝经与否、肿瘤大小、TNM分期、淋巴结转移无关,而Ki-67的表达与病理组织类型相关(P<0.05),且髓样癌组Ki-67表达均高于浸润性导管癌组,存在统计学意义。p53的表达与患者绝经与否、肿瘤大小、TNM分期无关,而p53的表达与患者年龄、淋巴结转移及肿瘤组织学分级相关(P<0.05),且在肿瘤组织学Ⅲ级中p53表达显著高于其在Ⅰ、Ⅱ级中的表达。结论 Ki-67、p53在TNBC中过表达,对判断TNBC的复发转移及预后有一定意义,是综合评价TNBC的重要标志物。Objective To research the expression and significance of Ki-67 and p53 in the triple-negative breast cancer（ TN- BC ） , and to explore its relationship with conventional clinicopathological prognostic indicators. Methods The immunohistochem- ical staining method was adopted to examine expressions of Ki-67 and p53 in 58 cases of TNBC ,and its relationship with clinico- pathological prognostic indicators was analyzed. Results The expressions of Ki-67 and p53 in TNBC group was significantly higher than NTNBC group （P 〈 0.05 ）. In TNBC group, the expression of Ki-67 was significantly correlated with pathological type, particularly significantly higher in medullary carcinoma group, but no with age, menopause, tumor size, TNM stage, lymph node metastasis. The expression of p53 was not related with menopause, tumor size and TNM staging, but with the age,lymph node me- tastasis and histological grade, p53 expression was higher in grade m cancer than in grade I and lI breast cancer. Conclusion The over-expressions of Ki-67 and p53 in TNBC have significance in predicting the recurrence ,metastasis and prognosis.

关 键 词：三阴性乳腺癌 KI-67 P53 免疫组化 

分 类 号：R737.9[医药卫生—肿瘤] R730.2[医药卫生—临床医学]