国产长春瑞滨联合顺铂治疗晚期乳腺癌的近期疗效观察  

Clinical observation on Vinorelbine plus Cisplatin in treatment of advanced metastatic breast cancer

作　　者：林尤恩[1] 王晓芬[1] 王春冰[1] 许宏伟[1] 邢佳鹏[1] 

机构地区：[1]揭阳市人民医院化疗二科,广东省揭阳522000

出　　处：《中国基层医药》2013年第15期2290-2292,I0001,共4页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的 评价国产长春瑞滨（NVB）联合顺铂（DDP）治疗多柔比星（ADM）或紫杉醇（raxol）耐药的晚期转移性乳腺癌的疗效及毒性.方法 选择既往使用ADM或TAXOL治疗后复发转移的晚期乳腺癌患者34例,其中单纯癌8例,浸润性导管癌20例,髓样癌3例,大汗腺样癌1例,硬癌2例.采用NVB25 mg/m2,DDP 25 mg/m2,静脉滴注.21 d为1个周期,每2～3个周期评定疗效.结果 完全缓解（CR）2例,部分缓解（PR） 18例,稳定（SD）8例,进展（PD）6例,总有效率（CR＋ PR）为58.8％ （20/34）.中位缓解期8.5个月,中位生存期18.3个月.主要毒性为骨髓抑制,Ⅲ～Ⅳ度白细胞下降发生率为50.0％ （17/34）.其他为恶心、呕吐、贫血、静脉炎等.结论 NVB联合DDP治疗ADM或TAXOL耐药的晚期转移性乳腺癌疗效确切,毒性反应可耐受,值得临床应用.Objective To observe the efficiency and toxicity of Vinorelbine（NVB） combined with Cisplatin （DDP） in the treatment of advanced breast cancer patients l＂esistent to Adriamycin （ADM） or Taxol treatment. Methods 34 patients with 8 cases simplex carcinoma,20 cases infiltrating duct carcinomas,3 cases medullary carci- noma, 1 case large sweat gland-like carcinoma and 2 cases scirrhous carcinoma, who were relaped and refractory after ADM or Taxol treatment, were treated with NVB 25mg/m2 ,DDP 25mg/m2, IV. Both drugs were given in a 21-days cycle. The efficacy was evaluated every 2 or 3 .cycles by using response evaluation criteria in solid tumor. Results 2 cases of 34 assessable patients achieved complete response （CR）, 18 patients had partial response （PR）, 8 cases had stable disease（ S D） ,6 cases had progressive disease（PD）. The total effective rate was 58.8% （ CR ＋ PR）. The medium duration of response and medium survival time were 8.5 months and 18.3 months, respectively. The pre- dominant toxicity was hematological,with grade III~ IV leukopenia occurring in 50.0% （17/34） patients. Other tox- icities were nausea, vomiting, anemia, phlebitis and so on. Conclusion The regimen of NVB combined with DDP is active and well tolerated, with an acceptable price, in treatment of advanced breast patients with refractory and re- lapsed after ADM or Taxol treatment.

关 键 词：乳腺肿瘤 药物疗法 长春瑞滨 顺铂 

分 类 号：R737.9[医药卫生—肿瘤]