黄芩药动学研究进展  

Research progress of pharmacokinetics study on Radix Scutellariae

作　　者：李晨睿[1] 牛银波[1] 潘亚磊[1] 翟远坤[1] 武祥龙[1] 范於菟[1] 梅其炳[1] 

机构地区：[1]西北工业大学生命学院空间生物实验模拟技术国防重点学科实验室,陕西西安710072

出　　处：《中国药理学通报》2013年第8期1048-1053,共6页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助项目(No 81202457;81073037);中国博士后科学基金(No 2012M521806)

摘　　要：黄芩来源于唇形科植物黄芩(Scutellariae baicalensisGeorgi)的干燥根,具有清热燥湿,泻火解毒,止血,安胎的功效,在传统中医药及现代中药制剂中黄芩得以广泛应用。黄芩富含黄酮类化合物,其口服生物利用度较低,并且在肠道吸收过程中发生显著的首过效应。该文对近年来黄芩提取物及其主要活性组分药物动力学方面的研究进展加以综述,并讨论其未来研究中应注意的问题。Radix Scutellariae is the dried root of Labiatae plant, Scutellariae baicalensis Georgi. It has broad therapeutic effects such as purging fire, moistening aridity, stoppage of bleeding and preventing miscarriage, and has been extensively applied in traditional medicine as well as modern pharmaceutics. Flavonoids are the major components in Radix Scutellariae, exhibiting low oral bioavailability due to the extensive first pass metab-olism during intestinal absorption. This paper reviews the research progress of the pharmacokinetics studies on the Radix Scutellariae extract and co-existing components and proposes the aspects which call for attention in its future research.

关 键 词：黄芩 黄酮类化合物 药物动力学 首过效应 药物间相互作用 Caco-2单层细胞模型 抗炎活性 

分 类 号：R05[医药卫生] R282.71